Results 111 to 120 of about 795,540 (289)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Combining estimators of a common parameter across samples
Statistical Theory and Related Fields, 2018 In many settings, multiple data collections and analyses on the same topic are summarised separately through statistical estimators of parameters and variances, and yet there are scientific reasons for sharing some statistical parameters across these ...
Eric Slud, Ilia Vonta, Abram Kagan
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Assessing spatiotemporal change in coral reef social-ecological systems
Ecology and SocietyCoral reef resilience is eroding at multiple spatial scales globally, with broad implications for coastal communities, and is thus a critical challenge for managing marine social-ecological systems (SESs).
Tarsha Eason, Ahjond Garmestani
doaj +1 more source
Prior-based Bayesian information criterion
Statistical Theory and Related Fields, 2019 We present a new approach to model selection and Bayes factor determination, based on Laplace expansions (as in BIC), which we call Prior-based Bayes Information Criterion (PBIC).
M. J. Bayarri +5 more
doaj +1 more source
Physical symmetries and Fisher's information measure
Physics Letters A, 2009 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Pennini, F. +3 more
openaire +5 more sources
Adaptive Designs for Optimal Observed Fisher Information
, 2019 Expected Fisher information can be found a priori and as a result its inverse is the primary variance approximation used in the design of experiments.
Lane, Adam
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Optimal Experimental Design for Fuel Cell Model Parameter Identification
IEEE AccessModel-based development provides a systematic approach for investigating fuel cell (FC) and fuel cell system (FCS) operation. It places particular emphasis on understanding reaction kinetics, transport phenomena, and aging mechanisms as functions of ...
Luis M. Winkler +2 more
doaj +1 more source