Results 111 to 120 of about 747,762 (279)
Lie Group Statistics and Lie Group Machine Learning Based on Souriau Lie Groups Thermodynamics & Koszul-Souriau-Fisher Metric: New Entropy Definition as Generalized Casimir Invariant Function in Coadjoint Representation. [PDF]
Entropy (Basel), 2020 Barbaresco F.
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Bayes Sensitivity with Fisher-Rao Metric
, 2014 We propose a geometric framework to assess sensitivity of Bayesian procedures to modeling assumptions based on the nonparametric Fisher-Rao metric. While the framework is general in spirit, the focus of this article is restricted to metric-based diagnosis under two settings: assessing local and global robustness in Bayesian procedures to perturbations ...
Kurtek, Sebastian, Bharath, Karthik
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Generalized Fubini-Study Metric and Fisher Information Metric
, 2015 We provide an experimentally measurable local gauge $U(1)$ invariant Fubini-Study (FS) metric for mixed states. Like the FS metric for pure states, it also captures only the quantum part of the uncertainty in the evolution Hamiltonian. We show that this satisfies the quantum Cramer-Rao bound and thus arrive at a more general and measurable bound.
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Copy of John Fisher's diary, made by him, 1776-1777
Typescript copy of diary entries made by John Fisher (1755-1843), the great-grandfather of George Brayton Fisher, for a period covering 14 July 1776 to 10 August 1777.
Fisher, John, 1755-1843;
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
, 2013 In lieu of an abstract, below is the essay\u27s first paragraph. I began my journey at St. John Fisher College in the fall of 2003; the education I received from Fisher was invaluable.
Hall, Shawn
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