Results 41 to 50 of about 54,351 (287)
Elasmobranch bycatch in US West Coast groundfish fisheries
Endangered Species Research, 2021 Effective management of multispecies fisheries in large marine ecosystems is challenging. To deal with these challenges, fisheries managers are moving toward ecosystem-based fishery management (EBFM).
JE Jannot +5 more
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Tataloka, 2016 The sustainable fisheries resources management at the Karimunjawa National Park (KNP) is a very complicated effort. One of the serious issues is that the national park was declared by government when it has been inhabited by fisherfolk community.
M Mussadun +3 more
doaj +1 more source
Seasonal variability shapes resilience of small-scale fisheries in Baja California Sur, Mexico. [PDF]
PLoS ONE, 2017 Small-scale fisheries are an important source of food and livelihoods to coastal communities around the world. Understanding the seasonality of fisheries catch and composition is crucial to fisheries management, particularly in the context of changing ...
Kara E Pellowe, Heather M Leslie
doaj +1 more source
Sustainability of capture fisheries management in small islands region (Case study in Regency of Sitaro Island, North Sulawesi) [PDF]
, 2021 Dionisius Bawole, Yolanda MTN Apituley
openalex +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Community knowledge as a cornerstone for fisheries management
Ecology and SocietyThe imperative to include stakeholders and rightsholders in fisheries management over the past 30 years has led to many changes in management regimes around the world, a key one being a move toward collaboration and co-management.
Kayla M. Hamelin +2 more
doaj +1 more source
Roles of Eco-labeling in Fisheries Conservation and Sustainability
Ilmu Kelautan, 2017 An important goal of fisheries management is to ensure that fish stocks are harvested at sustainable levels of fishing pressure. However, the classical maximum sustainable yield theory and its derivatives have not worked for fisheries management.
Olaniyi Alaba Olopade, Henry E. Dienye
doaj +1 more source