Results 51 to 60 of about 444,102 (282)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Snapper and grouper fisheries management in Aisandami using the EAFM approach [PDF]

open access: yesBIO Web of Conferences
The coastal waters of Aisandami are rich in diverse coral fish resources, including snappers and groupers. A study is needed to evaluate how fisheries are managed in water.
Sala Ridwan   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Livelihood Approaches and Fisheries Management in the Lower Mekong Basin [PDF]

open access: yes, 2006
Known as livelihood approaches, this new way of looking at fisheries management is becoming increasingly common, particularly with development agencies and other organisations. However, there is a perception that the concept of livelihoods and livelihood

core  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

MODEL PENGELOLAAN PERIKANAN BERBASIS HUKUM ADAT LAOT DI LHOK RIGAIH KABUPATEN ACEH JAYA

open access: yesMasalah-Masalah Hukum, 2011
The concept of fisheries management in Indonesia, local wisdom to know the content community, as the Regulation No. 4512009 and Regulation no. 1112006. This study wanted to address how the model-based fisheries management /aot customary law in Aceh. This
Sulaiman Sulaiman
doaj   +1 more source

Key Factors Supporting Small-Scale Coastal Fisheries Management [PDF]

open access: yes, 2014
This synthesis was designed to provide an evidence base on the success factors in small-scale coastal fisheries management in developing countries and, in turn, to assist the Rockefeller Foundation in developing its strategy for its Oceans and Fisheries ...
Emma Whittingham   +3 more
core  

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Me and My Behavior: An Experiment on Individual Characteristics and Compliance Behavior in Recreational Fishing

open access: yesFrontiers in Marine Science, 2020
Non-compliance with regulations is a complex problem in recreational fisheries management, having the potential to evoke uncertainty for conservation and socio-ecological outcomes and to undermine management efforts.
Mary Mackay   +9 more
doaj   +1 more source

Ecosystem Approach to Small Scale Tropical Marine Fisheries [PDF]

open access: yes, 2013
This is a 4-page brochure about a WorldFish led project. Throughout the world, poor fisheries management contributes to resource degradation, poverty, and food insecurity.
E. Kamanyi   +6 more
core  

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