Results 91 to 100 of about 172,580 (267)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
FishesNorthern shortfin squid (Illex illecebrosus) and longfin inshore squid (Doryteuthis pealeii) are fished commercially and recreationally off Atlantic Canada, but limited reporting, particularly from recreational fisheries, has left major gaps in our ...
Krista Dawn Baker +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
How can Fishery Comanagement Groups Enhance Economic Performance? Hints from Japanese Coastal Fisheries Management [PDF]
Although comanagement is gaining increasing attention as a way to manage fisheries, few studies have attempted to understand quantitatively which factors of comanagement are critical for their success. This study investigates fishery comanagement regimes
Wilen, James E., Uchida, Hirotsugu
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Economic Benefits of American Lobster Fishery Management Regulations [PDF]
A simulation model is used to compare measures for future management identified in the American lobster fishery management plan; specifically, increases in the minimum legal size and a modest reduction in aggregate fishing mortality are evaluated.
Richardson, Edwards J., Gates, John M.
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Fishery Policies and their Impact on the New Zealand Maori [PDF]
The introduction of innovative fishery policies in New Zealand has recently attracted international attention. The introduction of an ITQ system was premised on the notion of Crown ownership of fishery resources.
Cullen, Ross, Memon, Pyar Ali
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 1981 243 p.The goal of this plan is to manage the shrimp fishery of the United States waters of the Gulf of Mexico in order to attain the greatest overall benefit to the nation with particular reference to food production and recreational opportunities on the
Gulf of Mexico Fishery Management Council.
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