Results 101 to 110 of about 172,580 (267)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
An Approach to Ecosystem-Based Fishery Management [PDF]
Marine scientists and policymakers are encouraging ecosystem-based fishery management (EBFM), but there is limited guidance on how to operationalize the concept.
Lipton, Douglas W. +2 more
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Capital Dynamics in the North Sea Herring Fishery [PDF]
Dynamic adjustment is an integral part of natural resource economics. Commonly, capital is assumed to respond instantaneously to changes in profits, while in reality adjustment may take place only with a time lag.
Bjorndal, Trond, Conrad, Jon M.
core
Известия ТИНРОState of stocks and fishery and some general features of biology are considered for saffron cod in the Bering Sea on results of bottom trawl surveys and commercial fishery statistics in 2000–2023. In 2023, the stock in the southwestern part of the sea is
O. V. Novikova, L. A. Chernoivanova
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Russian fisheries: beginning of a new stage?
Известия ТИНРОState of the fishing industry in Russia is reviewed and preconditions are considered for transition from the historical principle of sharing quotas for catch to the principle of investment quotas.
A. N. Makoedov
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Study of phytoplankton community in coastal waters of Hormozgan province, Qeshm and Leangeh Islands [PDF]
بومشناسی آبزیان, 2015 The study of spatial and temporal variability of distribution of phytoplankton communities in Northern part of the Persian Gulf (Qeshm andLengeh Islands) was studied.
Gholamali Akbarzadeh +3 more
doaj
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source