Results 121 to 130 of about 172,580 (267)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
A Multi-Criteria Non-Linear Optimization Model for the Control and Management of a Tropical Fishery [PDF]
One of the principal problems when dealing with fishery resource management is to estimate strategies that satisfy biological, economic and social objectives simultaneously.
Seijo, Juan Carlos +1 more
core
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
MODELING THE EFFECTS OF AREA CLOSURE AND TAX POLICIES: A SPATIAL-TEMPORAL MODEL OF THE HAWAII LONGLINE FISHERY [PDF]
We develop an economic model for a multi-species fishery that incorporates the spatial and temporal distribution of effort and fish stocks. Catchability coefficients and initial stocks are estimated from catch and effort data for each specific location ...
Chakravorty, Ujjayant, Nemoto, Keiichi
core
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Jointness through fishing days input in a multi-species Fishery [PDF]
Some multi-species fisheries are characterised by production jointness in the sense that several species are caught through a joint production process (literally in the same haul of the net). Other multi-species fisheries (so called purse seine fisheries)
Carsten Lynge Jensen, Lars Gårn Hansen
core
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Optimal Capacity Decisions in a Developing Fishery [PDF]
The problem of estimating optimal fishing capacity for a developing fishery is discussed, using the methods of Bayesian decision analysis. The results obtained indicate that quite good decisions can often be made on the basis of limited prior information
Clark, Colin W. +3 more
core
Conservation Science and PracticeWildlife Management Areas (WMAs) represent a relatively new model for devolved, locally led conservation in Tanzania, wherein local villages set aside part of their land for wildlife conservation and manage that resource collectively.
Lily M. Duggan +8 more
doaj +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source