Results 121 to 130 of about 328,823 (297)

The Peruvian upwelling ecosystem: dynamics and interactions [PDF]

open access: yes
Upwelling, Ecosystems, Fishery biology, Fishery oceanography, Conferences, Peru,
Mendo, J.   +3 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Alternative Management Regimes for multiple species fisheries [PDF]

open access: yes
This empirical study examines welfare gains and losses that would result from alternative fishery management regimes. In an application to the North Sea demersal fisheries, the study shows that these fishery resources can give rise to large economic rent.
Kim, Chungsoo
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Study of phytoplankton community in coastal waters of Hormozgan province, Qeshm and Leangeh Islands [PDF]

open access: yesبوم‌شناسی آبزیان, 2015
The study of spatial and temporal variability of distribution of phytoplankton communities in Northern part of the Persian Gulf (Qeshm andLengeh Islands) was studied.
Gholamali Akbarzadeh   +3 more
doaj  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Using Citizen Science to Improve Our Understanding of Northern Shortfin Squid (Illex illecebrosus) and Longfin Inshore Squid (Doryteuthis pealeii) Ecology and Fisheries off Atlantic Canada

open access: yesFishes
Northern shortfin squid (Illex illecebrosus) and longfin inshore squid (Doryteuthis pealeii) are fished commercially and recreationally off Atlantic Canada, but limited reporting, particularly from recreational fisheries, has left major gaps in our ...
Krista Dawn Baker   +2 more
doaj   +1 more source

Bioeconomics of the Philippine small pelagics fishery [PDF]

open access: yes
Time series analysis of catch and effort data in the Philippines small pelagics fishery resulted in a level of biological and economic overexploitation.
Agâ¿ero, M.   +3 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

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