Results 131 to 140 of about 127,710 (318)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Optimal Capacity Decisions in a Developing Fishery [PDF]
The problem of estimating optimal fishing capacity for a developing fishery is discussed, using the methods of Bayesian decision analysis. The results obtained indicate that quite good decisions can often be made on the basis of limited prior information
Clark, Colin W. +3 more
core +1 more source
Community fishery resources management in Malalison Island, Philippines [PDF]
, 1995 The Community Fishery Resources Management Project, launched in 1991 in Malalison Island, Philippines is a development-oriented research project integrating biology, economics, sociology, engineering, and public administration.
Agbayani, Renato F.
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The Effects of Individual Vessel Quotas in the British Columbia Halibut Fishery [PDF]
Implementation of Individual vessel quotas (IVQs) in the British Columbia halibut fishery has provided a unique opportunity to examine the effects of this management technique on a previously intense "derby" fishery. This paper describes the changes that
Wilen, James E. +3 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
High-Grading in a Quota-Regulated Fishery, with Empirical Evidence from the Icelandic Cod Fishery [PDF]
Fishers in quota-regulated fisheries find it to their advantage to discard less valuable fish at sea to increase the value of their catch. A theoretical model describing the high-grading behavior of fishers is presented, and an empirical model is derived
Rickertsen, Kyrre, Kristofersson, Dadi
core +1 more source
The Donegal Mackerel Fishery [PDF]
, 1980 Irish Mackerel landings have increased dramatically, from less than 2,000 tonnes in 1970 to nearly 30,000 tonnes in 1978. The development of this fishery can be ensured only if a satisfactory management plan is drawn up.
Molloy, J, Kennedy, T D
core
Conservation Science and PracticeWildlife Management Areas (WMAs) represent a relatively new model for devolved, locally led conservation in Tanzania, wherein local villages set aside part of their land for wildlife conservation and manage that resource collectively.
Lily M. Duggan +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source