Results 151 to 160 of about 127,710 (318)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A BIOECONOMIC ANALYSIS OF MANAGEMENT ALTERNATIVES FOR THE U.S. NORTH ATLANTIC SWORDFISH FISHERY [PDF]

A bioeconomic model of the North Atlantic swordfish (Xiphias gladius) fishery is developed to evaluate policy-relevant management options as changes from the status quo.
Larkin, Sherry L., Adams, Charles M., Lee, Donna J.   +2 more
core   +1 more source

Strategic Priorities of Shipbuilding of a Fishery Complex of Russia

Управленческое консультирование, 2018
In the article tendencies of a condition of fleet of a fishery complex during the Post-Soviet period are considered and prerequisites for formation of measures of the state support of development of branch are analyzed.
Andrey Alfredovich Beletskiy
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Assessment of demersal fishery resources in Brunei Darussalam [PDF]

A problem commonly encountered in stock assessments of tropical marine resources in developing countries is data paucity, which invariably results from the lack of both human and economic capacity within the government to implement and maintain ...
Ebil, Syazana
core  

Modeling the drivers of trip satisfaction among Texas coastal anglers using creel survey data. [PDF]

PLoS One
Collins C, Paudel S, Harris E, Bauer H, Hawk R, Fisher M, Anderson J.   +6 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Fishing Location decisions in the Chilean-Transzonal Jack Mackerel Fishery [PDF]

This study examines factors conditioning the fishing location decisions of the Chilean fleet operating in the South-east Pacific straddling jack mackerel fishery, considering voyage data for the1987-2004 period.
Julio Peña Torres, Mabyr Valderrama
core  

Identification of métiers in a multi-gear, multi-species fishery. [PDF]

PLoS One
Leitão P, Castro M, Campos A.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source