Results 121 to 130 of about 352,929 (356)

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

open access: yesMolecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock   +10 more
wiley   +1 more source

PERSPECTIVE DIRECTIONS OF THE FISHING DEVELOPMENT INTERSKO-CASPIAN FISH INDUSTRIAL SUBREGION

open access: yesЮг России: экология, развитие, 2014
Aim. To work out perspective of stable fishing development in Tersko-Caspian fish industrial subregion.Location. Tersko-Caspian subregion.Methods. Analysis of own and literature materials according to the state of reserves and catches of the main food ...
A. S. Abdusamadov   +5 more
doaj   +1 more source

The Fishery Effects of Marine Reserves and Fishery Closures [PDF]

open access: yes, 2002
The Technical Centre for Agricultural and Rural Coordination (CTA) approved a project "Implementing the Caribbean Community Common Fisheries Policy: positioning and engaging fisherfolk organisations".

core  

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

open access: yesMolecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar   +4 more
wiley   +1 more source

Status of the spawning biomass of the Pacific sardine, 1983-84 [PDF]

open access: yes, 1984
State law provides for the initiation of a fishery for Pacific sardines, Sardinops sagax caeruleus, when the spawning biomass of sardines reaches 20,000 short tons.
Klingbeil, Richard A., Wolf, Patricia
core  

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

open access: yesMolecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy   +12 more
wiley   +1 more source

Fisheries in the Mediterranean

open access: yesMediterranean Marine Science, 2000
The aim of this paper is to give a description of the Mediterranean fisheries, and its level of exploitation and to address the main questions dealing with its management. The Mediterranean is a semi-enclosed marine area with generally narrow continental shelves. The primary production of the Mediterranean is among the lowest in the world (26-50g C m-2
Costas Papaconstantinou, H. Farrugio
openaire   +4 more sources

Population dynamics and fishery of dolphinfish (Coryphaena hippurus) in the western Mediterranean

open access: yesScientia Marina, 1999
The dolphinfish (Coryphaena hippurus) fishery based on the island of Majorca (western Mediterranean) and the population dynamics of the species were studied between 1995 and 1996.
Jordi Lleonart   +4 more
doaj   +1 more source

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

open access: yesMolecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen   +6 more
wiley   +1 more source

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