Results 171 to 180 of about 403,141 (345)

Large-scale historic habitat loss in estuaries and its implications for commercial and recreational fin fisheries

, 2022
Thomas Stamp, Elizabeth West, Tim Robbins, Shaun Plenty, Emma V. Sheehan   +4 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A Dataset on the Biodiversity Footprints and Sectoral Differences in China. [PDF]

Sci Data
Wang H, Wang L, Chen J, Ma P, Cui Y, Duan X.   +5 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Dispersal can spread management benefits: Insights from a modeled Fijian coral reef network. [PDF]

Ecol Appl
Greiner A, Andrello M, Krkošek M, Fortin MJ, Nand Y, Jupiter SD, Mangubhai S, Wenger A, Darling ES.   +8 more
europepmc   +1 more source

CURRENT MANAGEMENT AND EXTERNALITIES IN LOBSTER FISHERIES EXPLOITATION ON THE CONTINENTAL SHELF OF CEARÁ, BRAZIL

, 2015
João Vicente Mendes Santana, Soraya da Silva Neves, Soniamar Z. R. Saraiva, Charles M. Adams, Raúl Cruz   +4 more
openalex   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The complete mitochondrial genome of <i>Ptychidio longibarbus</i> (Cyprinidae) and its phylogenetic implications. [PDF]

Mitochondrial DNA B Resour
Zou M, Chen W.
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Effects of feeding different baits on the growth of Scylla paramamosain megalopa and the bacterial community in a mariculture system. [PDF]

Sci Rep
Liu Z, Xu L, Qiao G, Li Y, Ma C, Zhang F, Zhao M, Xu J, Ma L, Ma K, Wang W.   +10 more
europepmc   +1 more source