Results 171 to 180 of about 398,077 (310)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Maintaining ecological stability for sustainable economic yields of multispecies fisheries in complex food webs. [PDF]

Nat Commun
Werner AS, Hirt MR, Ryser R, Lancker K, Albert G, Quaas M, Rackauckas C, Gauzens B, Brose U.   +8 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Adjusting the management of the Antarctic krill fishery to meet the challenges of the 21st century. [PDF]

Proc Natl Acad Sci U S A
Meyer B, Arata JA, Atkinson A, Bahlburg D, Bernard K, Cárdenas CA, Grant SM, Hill SL, Hüppe L, Ichii T, Kawaguchi S, Krafft BA, Labrousse S, Maschette D, Piñones A, Reiss C, Siebenhüner B, Sylvester Z, Ziegler P.   +18 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Correction: Chronic hexavalent chromium exposure induces oxidative stress-mediated molecular cascades in Thymallus grubii gills: evidence from integrated transcriptomics and metabolomics. [PDF]

Front Immunol
Shang X, Che X, Ma K, Ma B, Sun H, Wu W, He H, Xing M, Xu W, Zhang Y.   +9 more
europepmc   +1 more source

emlab-ucsb/fisheries-behavior-change: Paper publication release

, 2020
Gavin McDonald
openalex   +1 more source

Atlantic bluefin tuna: population dynamics, ecology, fisheries and management [PDF]

, 2005
Jean‐Marc Fromentin, Joseph E. Powers
openalex   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Analysis of Relative Abundance Distribution and Environmental Differences for Blue Mackerel (<i>Scomber australasicus</i>) and Chub Mackerel (<i>Scomber japonicus</i>) on the High Seas of the North Pacific Ocean. [PDF]

Animals (Basel)
Zhang H, Zhu H, Zhang F, Huang S, Wang J, Xiang D, Li Y, Sun Y.   +7 more
europepmc   +1 more source