Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Removing observational noise from fisheries-independent time series data using ARIMA models [PDF]
, 2007 Abundance indices derived from fishery-independent surveys typically exhibit much higher interannual variability than is consistent with the within-survey variance or the life history of a species. This extra variability is essentially observation noise
Fogerty, Michael J. +1 more
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Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Pacific Hake, Merluccius productus, Autecology: A Timely Review [PDF]
, 2007 Pacific hake, Merluccius productus, the most abundant groundfish in the California Current Large Marine Ecosystem (CCLME), is a species of both commercial significance, supporting a large international fishery, and ecological importance, connecting ...
Cooke , Kenneth C. +4 more
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
The Application of Farm Programs to Commercial Fisheries: The Case of Crop Insurance for the Bristol Bay Commercial Salmon Fisheries [PDF]
Under the direction of the Agricultural Risk Protection Act of 2000, the U.S. Congress proposed a crop insurance program for the Bristol Bay, Alaska, commercial salmon fishery.
Geier, Hans +3 more
core +1 more source
South Lancashire Fisheries Advisory Committee 11th December, 1974 [PDF]
, 1979 This is the report from the South Lancashire Fisheries Advisory Committee meeting, which was held on the 11th December 1974. The report looks at information on the Water Bailiffs establishment, including the organisation and the duties of both the ...
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Increasing duration of heatwaves poses a threat to oyster sustainability in the Gulf of Mexico
Ecological IndicatorsThe future of the wild oyster fishery in the northern Gulf of Mexico is largely uncertain due to changing environmental conditions and declining abundance of harvestable oysters.
Jeffrey D. Plumlee +5 more
doaj +1 more source
Stranded Capital in Fisheries: The Pacific Coast Groundfish/Whiting Case [PDF]
Current rationalization options for West Coast groundfish trawl fisheries include significant allocations of harvester quota to processors, justified as compensation for “stranded capital.†This article discusses the origin of the concept of stranded ...
Wilen, James E.
core +1 more source