Results 111 to 120 of about 1,700 (296)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Application of Farm Programs to Commercial Fisheries: The Case of Crop Insurance for the Bristol Bay Commercial Salmon Fisheries

Under the direction of the Agricultural Risk Protection Act of 2000, the U.S. Congress proposed a crop insurance program for the Bristol Bay, Alaska, commercial salmon fishery.
Greenberg, Joshua A., Herrmann, Mark, Geier, Hans, Hamel, Charles   +3 more
core  

Deep learning models for the prediction of small-scale fisheries catches: finfish fishery in the region of “Bahía Magadalena-Almejas”

, 2018
Globally, over 80% of fisheries are at maximum sustainable levels or overexploited. However, small-scale fisheries (SSFs) in developing countries play a relevant role in coastal communities’ development with important impacts on the economy. The SSFs are
Ricardo Alberto Cavieses Núñez, Miguel Ángel Ojeda Ruiz de la Peña, Manuel Rodríguez Rodríguez, Alfredo Flores Irigollen   +3 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Marine Fishery Management Agent-Based Modeling

, 2022
Fisheries in the United States not only provide seafood for us to enjoy and contribute significantly to the American economy, they also help us to sustain ecological balance and protect our ocean resources.
Sato, Hiroki
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

E-poster on Marine Fisheries Forecasts Case Study

, 2020
This e-poster details the marine fisheries forecast case study from Blue-Action. The poster is designed to be viewed dynamically. It was presented at the MASTS conference, UK, in 2019.
openaire   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Structural Vector Error Correction Modeling of Integrated Sportfishery Data

We demonstrate how to specify and estimate a time series model that can isolate the effects of changes in fishery policy and forecast the outcome of policy changes in the context of changing climate and economic factors.
Carter, David W., Letson, David
core  

Increasing duration of heatwaves poses a threat to oyster sustainability in the Gulf of Mexico

Ecological Indicators
The future of the wild oyster fishery in the northern Gulf of Mexico is largely uncertain due to changing environmental conditions and declining abundance of harvestable oysters.
Jeffrey D. Plumlee, Sean P. Powers, David L. Kimbro, John C. Lehrter, Jason Herrmann, John Mareska   +5 more
doaj   +1 more source