Results 111 to 120 of about 439,875 (265)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Economic Benefits of American Lobster Fishery Management Regulations [PDF]
A simulation model is used to compare measures for future management identified in the American lobster fishery management plan; specifically, increases in the minimum legal size and a modest reduction in aggregate fishing mortality are evaluated.
Richardson, Edwards J., Gates, John M.
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Fishery Policies and their Impact on the New Zealand Maori [PDF]
The introduction of innovative fishery policies in New Zealand has recently attracted international attention. The introduction of an ITQ system was premised on the notion of Crown ownership of fishery resources.
Cullen, Ross, Memon, Pyar Ali
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
, 1981 243 p.The goal of this plan is to manage the shrimp fishery of the United States waters of the Gulf of Mexico in order to attain the greatest overall benefit to the nation with particular reference to food production and recreational opportunities on the
Gulf of Mexico Fishery Management Council.
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Capital Dynamics in the North Sea Herring Fishery [PDF]
Dynamic adjustment is an integral part of natural resource economics. Commonly, capital is assumed to respond instantaneously to changes in profits, while in reality adjustment may take place only with a time lag.
Bjorndal, Trond, Conrad, Jon M.
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Increasing duration of heatwaves poses a threat to oyster sustainability in the Gulf of Mexico
Ecological IndicatorsThe future of the wild oyster fishery in the northern Gulf of Mexico is largely uncertain due to changing environmental conditions and declining abundance of harvestable oysters.
Jeffrey D. Plumlee +5 more
doaj +1 more source