Results 91 to 100 of about 1,700 (296)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Pengembangan Model Simulasi Kebijakan Pengelolaan Ikan Berkelanjutan
Jurnal Teknik Industri, 2012 Stock assessment studies of Sardinella Lemuru Bali strait indicate overfishing. The growth of fishing vessel numbers result on fish biomass stock reduction.
Ratna Purwaningsih +2 more
doaj
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Remote SensingThis paper aims to explore the impact of marine ranching construction on water quality and fishery resources in the surrounding marine areas. Utilizing in situ water quality and fishery resource data collected before and after the establishment of marine
Jianqu Chen +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A model base system for sustainable development of marine fishery
, 2014 Model Base System for Marine Fishery Services is a type of software system which can classify and maintain a large number of models in the f ield of marine fishery, and support their generation, storage, query, running and analysis. This system can be ut
Yang, J. +4 more
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Results of economic usage of the pacific salmon resources in the Sakhalin-Kuril region in 2023
Известия ТИНРОPacific salmon fishery in the Sakhalin-Kuril region in 2023 is considered. The landing of 78.2.103 t was forecasted but the actual annual catch was 75.8.103 t or 97 % of the forecast. This ratio was the following for the mass species: pink salmon — 34643
A. A. Makoedov +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source