Results 111 to 120 of about 24,141 (262)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Pink salmon fishery in the European part of Russia: results for 2023

Известия ТИНРО
Pink salmon is currently the main species for the anadromous fish fishery in the north of the European part of Russia. Upward trends were observed in this species returns and catches in odd years of the 2013–2021 in the regions of North-West Russia ...
I. I. Gordeev, A. V. Tkachenko, A. M. Tortsev, I. I. Studionov, E. A. Genrikh, A. N. Kanzeparova, V. A. Belyaev   +6 more
doaj   +1 more source

THE CALIFORNIA ROCKFISH CONSERVATION AREA AND GROUNDFISH TRAWLERS AT MOSS LANDING HARBOR [PDF]

This article uses a bioeconomic model and data for groundfish trawlers at Moss Landing Harbor in Central California to analyze effects of spatial closures that were implemented recently by West Coast fishery managers to reduce bycatch of overfished ...
Dalton, Michael G., Ralston, Stephen
core   +1 more source

Eden Fisheries Advisory Committee 3rd December, 1974 [PDF]

, 1974
This is the report from the Eden Fisheries Advisory Committee meeting, which was held on the 3rd December 1974. The report looks at information on the Water Bailiffs establishment, including the organisation and the duties of both the Fisheries Inspector

core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

ABSTRACTS: CONTRIBUTED PAPERS [PDF]

Teaching/Communication/Extension/Profession,
Anonymous
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Pink salmon fishery in the Far-Eastern fishing basin in 2023: preliminary studies, forecast, interpretation of the fishing season results

Известия ТИНРО
Data of the trawl surveys for counting of pink salmon in 2022 and 2023 and results of pink salmon fishery in the main areas of the Russian Far East in 2023 are presented and the studies for understanding the state of the main pink salmon stocks and ...
E. A. Shevlyakov, A. A. Somov, V. A. Shevlyakov, A. N. Kanzeparova, N. A. Dederer, I. V. Melnikov   +5 more
doaj   +1 more source