Results 141 to 150 of about 3,429,512 (335)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Research on the Evolution Characteristics and Laws of China's Fishery Policy-Word Quantitative Analysis Based on the Texts of 250 Normative Documents Related to Fisheries

Haiyang Kaifa yu guanli
China is the world's largest fishery country and also the world's largest aquaculture country. Fisheries is a very important industry in the national economy and has a significant impact on maintaining and improving the quality of people's lives ...
ZHANG Hui, YANG Huaiyu
doaj  

Aquaculture-driver of the fisheries industry

E3S Web of Conferences
Based on a generalization of an extensive array of statistical and analytical data, an analysis of the state of the fishery complex of Russia and the Krasnodar Territory was carried out. The industry’s contribution to solving the problem of food security has been determined. A fairly high degree of self-sufficiency of Russians in fish products has been
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Integrating Porpoise and Cod Management: A Comparison of Days-at-sea, ITQs, and Closures [PDF]

The purpose of this study is to determine if management measures based on effort reductions, in particular days-at-sea (DAS) controls, can approach a harbor porpoise individual transferable quotas (ITQ) program in terms of efficiency.
Bisack, Kathryn D.
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Impact of Maritime Power Strategy on High Quality Development of Fishery Economy: Taking China's Coastal Areas as an Example

Haiyang Kaifa yu guanli
Studying the policy effects of the strategy of maritime power is of great guiding significance for cultivating new dynamic energy of the ocean economy and promoting the high-quality development of the fishery economy in coastal areas.
WU Zhengjie, MA Jintao, HU Qiuguang
doaj  

Characterization of Large Yellow Croaker Quality in Different Culture Modes and Sizes

Progress in Fishery Sciences
Large yellow croaker (Larimichthys crocea) fish are a major marine aquaculture product in China. They mainly farmed in nearshore floating cages, but the irrational layout of nearshore aquaculture and high aquaculture density seriously affect the flesh ...
Weibo SUN, Banghong WEI, Xiaomei ZHUANG, Yuan MA, Caiwen DONG, Quanyou GUO   +5 more
doaj   +1 more source

An impact and adaptation assessment of changing coastal fishing grounds and fishery industry under global change

Mitigation and Adaptation Strategies for Global Change, 2020
Ching-Hsien Ho, N. Yagi, Yongjun Tian
semanticscholar   +1 more source