Results 81 to 90 of about 968,453 (286)

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

open access: yesFEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Strategic Study for Sustainable Development of Freshwater Aquaculture in Camagüey

open access: yesRevista de Producción Animal, 2018
A strategic study of biological-fishing behavior of the main variables determined for extensive freshwater aquaculture was made in facilities of the Camagüey Fishing Company, province of Camagüey, Cuba.
Pedro Enrique Ramírez Fernández   +2 more
doaj  

The role of women in fish processing: handling and marketing in Kainji Lake basin [PDF]

open access: yes, 2005
The study assessed the contribution of women in fish handling, processing and marketing in Kainji Lake basin. Structured questionnaires were administered to three fishing villages selected at random.
Bako, W.S.
core  

Social change, ecology and climate in 20th-century Greenland [PDF]

open access: yes, 2000
Two great transitions, from seal hunting to cod fishing, then from cod fishing to shrimp, affected population centers of southwest Greenland during the20th century.
Hamilton, Lawrence C.   +2 more
core   +2 more sources

On the creeping increase of vessels’ fishing power

open access: yesEcology and Society, 2019
This contribution presents a synthesis, via a semilogarithmic regression, of estimates of the slow increase of technological efficiency, or “creep factor,” as estimated by various authors for a number of demersal and pelagic fisheries.
M. Palomares, D. Pauly
semanticscholar   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Mathematical substantiation of parameters of safe pelagic trawling in the canyon [PDF]

open access: yesVestnik MGTU, 2015
The authors have offered and proved the following security options of pelagic trawling in the sea canyon: the tolerance of the vessel from the optimal track; the minimum width of the canyon giving opportunity for the conditions to ensure the safety of ...
Danilov Yu. A., Ermakov S. V.
doaj  

Species Trends in Sport Fisheries, Monterey Bay, Calif., 1959-86 [PDF]

open access: yes, 1995
Three surveys spanning 28 years were examined for changes in species caught by recreational fishermen from small boats (skiffs) and commercial passenger fishing vessels (CPFV's) in California's Monterey Bay region.
Mason, Janet E.
core  

Hog Daddy and the Walls of Steel: Catch Shares and Ecosystem Change in the New England Groundfishery [PDF]

open access: yes, 2014
The U.S. National Oceanic and Atmospheric Administration implemented marketbased fishery management in the New England groundfishery as catch shares, controlling aggregate harvests through tradable annual catch quotas allocated to fishing groups called ...
Brewer, Jennifer F
core   +2 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

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