Results 91 to 100 of about 863,290 (309)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Mathematical substantiation of parameters of safe pelagic trawling in the canyon [PDF]
Vestnik MGTU, 2015 The authors have offered and proved the following security options of pelagic trawling in the sea canyon: the tolerance of the vessel from the optimal track; the minimum width of the canyon giving opportunity for the conditions to ensure the safety of ...
Danilov Yu. A., Ermakov S. V.
doaj
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
The Journal of Thoracic and Cardiovascular Surgery, 2016 Dirk J, Varelmann, Michael N, D'Ambra
openaire +2 more sources
Fishing Across the Centuries: What Prospects for the Venice Lagoon? [PDF]
Fishing has always been an important activity for those Venetians who live near the Lagoon, and it still enjoys an important economic and social role in the region.
M. Pellizzato +2 more
core
Responsible fisheries enhancing poverty alleviation of fishing communities of Lake Kainji [PDF]
, 2005 The attributes of responsible fisheries in enhancing Poverty Alleviation of fishing Communities of Lake Kainji were appraised. After impoundment in 1968, the catch per unit effort of fish continued on a downward trend, which suggested a decline in the ...
Abiodun, J.A. +5 more
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Seasonal Changes in Blood Parameters in Juvenile Cyprinus carpio
Scientific Papers Animal Science and Biotechnologies, 2023 Temporal variations in the biochemical and haematological parameters of blood must be taken into account as it is a useful indicator for assessing the nutritional status, non-specific immunity and health of fish in general.
Elena Eugenia Mocanu +3 more
doaj
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source