Results 81 to 90 of about 76,401 (269)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Mathematical substantiation of parameters of safe pelagic trawling in the canyon [PDF]
Vestnik MGTU, 2015 The authors have offered and proved the following security options of pelagic trawling in the sea canyon: the tolerance of the vessel from the optimal track; the minimum width of the canyon giving opportunity for the conditions to ensure the safety of ...
Danilov Yu. A., Ermakov S. V.
doaj
Cytogenetic and Genome Research, 2013 In fishes, as in other vertebrate species, the DNA component of the telomeres consists of the tandemly repeated TTAGGG motif. The length of the telomeric arrays in fishes ranges from 2 to 25 kb and shortens with age in some of the species. To date, chromosomal distribution of the telomeric DNA sequences has been examined in approximately 80 fish ...
openaire +2 more sources
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Scientific ReportsThe use of artificial light is a common strategy in purse seine fisheries, particularly in Zone C waters off Kuala Terengganu, where it enhances aggregation of pelagic species.
Mohd Samsul Rohizad Maidin +2 more
doaj +1 more source
Seasonal Changes in Blood Parameters in Juvenile Cyprinus carpio
Scientific Papers Animal Science and Biotechnologies, 2023 Temporal variations in the biochemical and haematological parameters of blood must be taken into account as it is a useful indicator for assessing the nutritional status, non-specific immunity and health of fish in general.
Elena Eugenia Mocanu +3 more
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Discover OceansLength–weight relationship (LWR) analysis is a fundamental tool for assessing growth patterns, population health, and ecological status of fish species. This study examined the relationship between body length and weight, size–frequency distribution, and
Nurul Iman Athirah Hamdan +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source