Results 101 to 110 of about 231,819 (317)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Media advocacy for farm safety and health: current landscape and future directions
BMC Public HealthBackground Within public health, media advocacy embraces the influence of new media and journalists in setting public agendas and promoting important public health programming and policies.
Pamela J. Milkovich +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
A Model of Fishing Conflicts in Foreign Fisheries [PDF]
Coastal nations can impose conditions of use on foreign fishing firms that operate in their Exclusive Economic Zone. We develop a game-theoretical model in which a fishery owner maximizes the revenue that it collects from firms that operate in its EEZ by
Yoav Wachsman
core
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Fishing Location decisions in the Chilean-Transzonal Jack Mackerel Fishery [PDF]
This study examines factors conditioning the fishing location decisions of the Chilean fleet operating in the South-east Pacific straddling jack mackerel fishery, considering voyage data for the1987-2004 period.
Julio Peña Torres, Mabyr Valderrama
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
The Value of Recreational Inshore Marine Fishing
The relative values of New Zealand commercial and recreational marine fishing are unknown. Value transfer is applied to assess the likely value of inshore marine recreational fishing.
Kerr, Geoffrey N., Latham, N.
core