Results 81 to 90 of about 388,975 (339)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Development of the South Canterbury / Otago southern bluefin tuna fishery [PDF]
, 1983 There is concern that many of New Zealand's inshore fish species are being overfished to the extent that fishing effort will have to be reduced to ensure the continued existence of some species as commercial stocks.
O'Donnell, D. K., Sandrey, R. A.
core
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
A database of mapped global fishing activity 1950–2017
Scientific DataA new database on historical country-level fishing fleet capacity and effort is described, derived from a range of publicly available sources that were harmonized, converted to fishing effort, and mapped to 30-min spatial cells.
Yannick Rousseau +6 more
doaj +1 more source
Southern California private-boat sport fishermen: how familiar are they with the sport fishing regulations? [PDF]
, 1980 Anglers frequently violate sport fishing regulations out of ignorance, by mistake, or by deliberate action. To determine whether unfamiliarity with the regulations plays a major part in this problem, we asked anglers on privately-owned, trailerable ...
Wine, Vickie L.
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
The Drama of Fishing Commons: Cournot-Nash Model and Cooperation [PDF]
Cournot-Nash model; drama of the commons; cooperation; game theory; fishing effort.
José António Filipe
core