Results 31 to 40 of about 25,649 (133)

Extranodal Marginal Zone Lymphoma: Integrating Etiology, Microenvironment, and Genetics Into Clinical Decision‐Making

European Journal of Haematology, EarlyView.
ABSTRACT Extranodal marginal zone lymphoma (EMZL) represents a unique paradigm among indolent B‐cell neoplasms, in which lymphomagenesis is frequently driven by chronic antigenic stimulation within tissue‐specific microenvironments. Persistent infectious or autoimmune triggers promote the development of ectopic lymphoid tissue and sustain B‐cell ...
Mamdouh Skafi, Santino Caserta, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Marco Fiorillo, Eugenio Lucia, Graziella D'Arrigo, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Maria Eugenia Alvaro, Giovanni Tripepi, Fortunato Morabito, Massimo Gentile   +15 more
wiley   +1 more source

Bridging Randomized Trial Efficacy and Real‐World Effectiveness in Multiple Myeloma: Integrating Clinical Trials and Real‐World Evidence for Individualized Care

European Journal of Haematology, EarlyView.
ABSTRACT Multiple myeloma (MM) is predominantly a disease of older adults, yet the randomized clinical trials (RCTs) that define standards of care are conducted largely in younger, fitter, and less comorbid populations. This creates a systematic mismatch between the populations generating evidence and those receiving treatment in routine practice ...
Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Santino Caserta, Eugenio Lucia, Graziella D'Arrigo, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Maria Eugenia Alvaro, Giovanni Tripepi, Fortunato Morabito, Massimo Gentile   +13 more
wiley   +1 more source

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

The FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz, Daniel Pérez‐Calixto, Jorge Carretero‐Ortega, Aida Gabriela Guzman‐López, Diana Cristina Pinto‐Dueñas, Mariana Hernández‐Juárez, Alejandra Jiménez‐Escobar, Adriana Rodríguez‐Hernández, Beatriz Díaz‐Bello, Nathalia Serna‐Márquez, Miguel Ángel Peña‐Rico, Laura Gómez‐Romero, Francisco Gabriel Vázquez‐Cuevas, Genaro Vázquez‐Victorio   +13 more
wiley   +1 more source

Modeling of the geographical distribution of two forest‐forming fucoids in the Strait–Alboran demarcation (southern Iberian Peninsula): Implications for conservation and restoration

Journal of Phycology, EarlyView.
Abstract Marine forests formed by canopy‐forming brown algae of the former Cystoseira complex are key habitat‐forming components of Mediterranean coastal ecosystems, supporting biodiversity and multiple ecosystem functions. However, many populations have declined in recent decades due to increasing anthropogenic pressures and climate change, raising ...
Pablo Pérez‐Castro, Elena Bañares‐España, Antonio Flores‐Moya, Ignacio J. Melero‐Jiménez   +3 more
wiley   +1 more source

Levodopa and Melanoma: Practical Recommendations for Parkinson's Disease—International Parkinson and Movement Disorder Society Scientific Issues Committee Viewpoint

Movement Disorders Clinical Practice, EarlyView.
Giorgia Sciacca, Inas Elsayed, Santiago Perez‐Lloret, Tiago F. Outeiro, Vivek K. Unni, Jeffery H. Kordower, Daniela Berg, Lorraine V. Kalia, on behalf of the MDS Scientific Issues Committee, Jane Alty, Alexander Balck, Daniela Berg, Per Borghammer, Inas Elsayed, Yue Huang, Walaa Kamel Elsayed, Jeffrey Kordower, Alexander Lehn, Michele Matarazzo, Tiago Mestre, Tiago Outeiro, Gian Pal, Santiago Perez Lloret, Roopa Rajan, Sephira Ryman, Giorgia Sciacca, Per Svenningsson, Lorraine Kalia   +27 more
wiley   +1 more source

Fluctuating asymmetry based on fractal geometry does not track environmental stress in an intertidal habitat‐forming fucoid

Journal of Phycology, EarlyView.
Abstract The availability of easy‐to‐measure and inexpensive biomarkers is a challenge for monitoring environmental stress in organisms. Although it has been proposed that non‐directional deviations from a symmetrical pattern in morphological traits (called fluctuating asymmetry.
Antonio Flores‐Moya, Ignacio J. Melero‐Jiménez, María J. García‐Sánchez, Elena Bañares‐España   +3 more
wiley   +1 more source

Acid-base balance in the elderly

Revista de Nefrología, Diálisis y Trasplante, 2019
Aging is a physiological process characterized by progressive deterioration of organ functions, where the ability to adapt and respond to a stressful situation is reduced.
Jesús Salvador Sánchez-Díaz, Enrique Antonio Martínez-Rodríguez, Karla Gabriela Peniche-Moguel, Enrique Monares-Zepeda, Luis Del Carpio-Orantes, Orlando Rubén Nieto-Pérez, Eder Iván Zamarrón-López, María Verónica Calyeca-Sánchez   +7 more
doaj  

Houssay, Leloir y los nóbeles latinoamericanos de ciencias

Revista Colombiana de Endocrinología, Diabetes y Metabolismo, 2017
La ciencia latinoamericana tuvo un auge con los investigadores del Cono Sur, en particular argentinos, siendo tres de ellos galardonados con el premio Nobel.
Alfredo Jácome Roca
doaj   +1 more source

Extreme Polyploidy Reveals Functional Trade‐Offs in Plant Drought Responses

Plant, Cell &Environment, EarlyView.
ABSTRACT Polyploidy shapes plant physiology and anatomy, yet the extent to which different ploidy levels influence drought responses remains unclear. Here, we investigated how ploidy affects cell‐level coordination and functional traits associated with water transport and retention.
Javier López‐Jurado, Enrique Mateos‐Naranjo, Francisco Balao, Ajaree Thonglim, Frederic Lens, Timothy J. Brodribb   +5 more
wiley   +1 more source

Mecanismos de patogénesis del melanoma maligno

Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica, 2012
El melanoma es una de las neoplasias malignas de la piel más agresivas y peligrosas. Tiene múltiples factores de riesgo, siendo uno de los más importantes la exposición crónica e intermitente al sol.
Catalina Restrepo, Margarita María Velásquez   +1 more
doaj   +1 more source