Results 31 to 40 of about 29,337 (227)

Standardized Microplate‐Based Assays for Quantifying Antioxidant Activity in Extracellular Vesicles and Nanovesicles Across Biological Kingdoms

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 11, November 2026.
ABSTRACT The antioxidant activity of extracellular vesicles (EVs) and nanovesicles are increasingly linked to their physiological and therapeutic functions, yet its accurate quantification remains limited by low EV yield, co‐isolated contaminants and the lack of standardized methodologies.
Juan Antonio Nieto   +15 more
wiley   +1 more source

Effect of primary lesions in cytoskeleton proteins on red cell membrane stability in patients with hereditary spherocytosis

open access: yesFrontiers in Physiology, 2022
We investigated by targeted next generation sequencing the genetic bases of hereditary spherocytosis in 25 patients and compared the molecular results with the biochemical lesion of RBC membrane obtained by SDS-PAGE analysis.
Cristina Vercellati   +7 more
doaj   +1 more source

CP32, a novel anti‐oomycete cyclic peptide, interferes with cell‐wall deposition in Phytophthora infestans

open access: yesJournal of Integrative Plant Biology, Volume 68, Issue 11, Page 4013-4029, November 2026.
The small cyclic peptide CP32 effectively inhibits Phytophthora infestans, the causal agent of potato and tomato late blight. Combined biochemical and phenotypic analyses demonstrate that CP32 disrupts cell wall biosynthesis, a key process in pathogen infection, resulting in a marked reduction of disease symptoms in plants.
Demetrio Marcianò   +23 more
wiley   +1 more source

Variaciones hematológicas en ovejas infectadas experimentalmente con trypanosoma vivax

open access: yesRevista Científica, 2010
Con el objeto de conocer la fisiopatología de la anemia que un aislado venezolano de T. vivax provoca en pequeños rumiantes, 9 ovejas mestizas West-African de 2 años de edad y 25,9 Ó 3 kg promedio de peso, se seleccionaron con el uso de la tabla de
E. Sandoval, E. Espinosa, A. Valle
doaj  

Early‐Life Betaine Supplementation Drives Sex‐Specific Metabolic Programming in Rats, Affecting FGF21 Signaling and Energy Balance

open access: yesThe FASEB Journal, Volume 40, Issue 20, 31 October 2026.
A maternal western diet (WD) and betaine supplementation during suckling influence metabolic programming. A maternal WD induced adverse metabolic effects in offspring, accompanied by altered FGF21‐related gene expression and decreased Akkermansia muciniphila abundance.
Rocío A. Martín‐Chamorro   +4 more
wiley   +1 more source

Eltrombopag Added to Standard Immunosuppressive Treatment as Front‐Line Therapy for Severe Aplastic Anemia: Long‐Term Outcomes of the Phase‐3 Randomized Superiority EBMT‐SAAWP RACE Study

open access: yesAmerican Journal of Hematology, Volume 101, Issue 10, Page 2520-2532, October 2026.
ABSTRACT The RACE study (NCT02009747) compared horse antithymocyte globulin (hATG) plus cyclosporine A (CsA) ± eltrombopag as initial immunosuppressive treatment (IST) for severe aplastic anemia. Here we report the final 2‐year analysis of this prospective randomized phase III study.
Antonio M. Risitano   +52 more
wiley   +1 more source

Transtornos afetivos: pesquisa e perspectivas para o futuro

open access: yesBrazilian Journal of Psychiatry, 1999
Neste breve comentário, áreas particularmente promissoras de pesquisa básica e clínica que visam elucidar a etiologia e fisiopatologia dos transtornos afetivos são sumarizadas. Perspectivas para pesquisa e desenvolvimento futuro são brevemente discutidas,
Soares Jair C.
doaj  

Genética e fisiopatologia dos transtornos depressivos

open access: yesBrazilian Journal of Psychiatry, 1999
Fatores genéticos, neurobiológicos e ambientais participam da gênese das depressões. Esta breve revisão visa enfatizar os estudos sobre os aspectos genéticos, neuroquímicos e neuroanatômicos na etiologia e fisiopatologia das depressões e suas implicações
Beny Lafer, Homero Pinto Vallada Filho
doaj   +1 more source

Eating Behavior Latent Profiles and Their Associations With Body Composition in Early Childhood: The CORALS Cohort

open access: yesObesity, Volume 34, Issue 10, Page 1904-1914, October 2026.
ABSTRACT Objective This study aimed to identify sex‐specific eating behavior profiles and assess the associations between eating behaviors subscales and profiles and body composition indices in Spanish preschoolers from the CORALS cohort. Methods We conducted a cross‐sectional analysis of baseline data from 1208 children aged 3–6 years (50.1% girls ...
Andrea Jimeno‐Martínez   +24 more
wiley   +1 more source

Fisiopatologia das doenças falciformes: da mutação genética à insuficiência de múltiplos órgãos The pathophysiology of sickle cell disease: from the genetic mutation to multiorgan disfunction

open access: yesRevista Brasileira de Hematologia e Hemoterapia, 2007
As principais alterações fisiopatológicas das doenças falciformes são revistas, levando em conta três níveis: a) moléculas e células, b) tecidos, c) organismo completo.
Marco Antonio Zago   +1 more
doaj   +1 more source

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