Results 111 to 120 of about 592,269 (288)
GCN2 in proteostasis: structural logic, signalling networks and disease
The FEBS Journal, EarlyView.Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
Live fast, die fast principle in a single cell of fission yeast [PDF]
, 2017 Growth and death are both fundamental macroscopic properties for all living matters, and thus cell division and mortality rates are good parameters for characterizing cellular physiology in a given environment.
Hidenori Nakaoka
core +1 more source
Chromatin remodeler Fft3 plays a dual role at blocked DNA replication forks
Life Science Alliance, 2019 Fft3, a member of the SNF2 family of ATPase-dependent enzymes, plays a dual role at DNA replication barriers in fission yeast by promoting both DNA resection and restart of blocked DNA replication forks. Here, we investigate the function of fission yeast
Anissia Ait-Saada +7 more
doaj +1 more source
The FEBS Journal, EarlyView.Homologous recombination (HR) in Schizosaccharomyces pombe is essential when mating‐type switching–induced double‐strand breaks (DSBs) form at the mat1 locus. In h90 and h− strains, efficient mat1 DSB formation renders HR indispensable unless suppressors block these breaks.
Peter Kolesar +3 more
wiley +1 more source
The highly dynamic heterochromatin protein Swi6 mediates degradation of heterochromatic transcripts [PDF]
, 2014 The aim of my thesis was to investigate the mechanism of heterochromatin repression mediated by heterochromatin protein Swi6 in S. pombe. Research over the years challenged the view of heterochromatin as a static and transcriptionally inert structure ...
Stunnenberg, Rieka
core +1 more source
PomBase: The Scientific Resource for Fission Yeast [PDF]
, 2018 The fission yeast Schizosaccharomyces pombe has become well established as a model species for studying conserved cell-level biological processes, especially the mechanics and regulation of cell division. PomBase integrates the S. pombe genome sequence with traditional genetic, molecular and cell biological experimental data as well as the growing body
Lock, A +3 more
openaire +3 more sources
Biology Open, 2014 Summary Target of rapamycin complex 1 (TORC1), which controls growth in response to nutrients, promotes ageing in multiple organisms. The fission yeast Schizosaccharomyces pombe emerges as a valuable genetic model system to study TORC1 function and ...
C. Rallis +4 more
semanticscholar +1 more source
Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants
The FEBS Journal, EarlyView.Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan +19 more
wiley +1 more source
, 2021 TOR complex 1 (TORC1) is a multi-subunit protein kinase complex that controls cellular growth in response to environmental cues. The regulatory subunits of mammalian TORC1 (mTORC1) include RAPTOR (also known as RPTOR), which recruits mTORC1 substrates ...
25979 +13 more
core +1 more source
Fission yeast meets a legend in Kobe: report of the Eighth International Fission Yeast Meeting [PDF]
Genes to Cells, 2015 The Eighth International Fission Yeast Meeting, which was held at Ikuta Shrine Hall in Kobe, Japan, from 21 to 26 June 2015, was attended by 327 fission yeast researchers from 25 countries (190 overseas and 137 domestic participants). At this meeting, 124 talks were held and 145 posters were presented.
Haruhiko, Asakawa +2 more
openaire +2 more sources