Results 131 to 140 of about 799,230 (312)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Similar body composition outcomes following volumetric diet and time-restricted eating in middle-aged individuals: a 12-week randomized controlled trial

Nutrition Journal
Introduction Overweight and obesity are increasing global challenges associated with severe health risks. Lifestyle factors like easy access to high-caloric foods and a decrease in physical activity contribute to weight gain. The increase in fat mass (FM)
Alicia Cloos, Stephan Geisler, Eduard Isenmann   +2 more
doaj   +1 more source

fitness

, 2014
Fitness estimates for each strain relative to the isogenic phage free strain. The proportion of lysogens identified among the originally phage free competitor strain is also estimated and total densities of each strain ...
Nicola Burns (3319767), Burns, Nicola, Harrison, Ellie, James, Chloe E., Ellie Harrison (3248199), Chloe E. James (3319764)   +5 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Current status and related factors of breakfast skipping among adolescents aged 12–15 years in Shandong Province, China: a cross-sectional study

BMC Public Health
Background Regular breakfast consumption is essential for adolescent health, providing critical nutrients for growth, development, and cognitive performance. However, breakfast skipping remains prevalent among adolescents globally and has been associated
Zhihao Huang, Qing Zhang, Chunyang Li, Hanhui Liu, Kunzong Tian   +4 more
doaj   +1 more source

Association Between Abnormal Body Weight and Physical Fitness Levelsin Chinese Older Adults: Findings from the 5th National PhysicalFitness Surveillance in China

Xiehe Yixue Zazhi
ObjectiveBased on the data from the 5th National Physical Fitness Surveillance in China, this study aimed to explore the relationship between abnormal body weight and physical fitness levels in older adults.MethodsThe study included adults aged 60-79 ...
FAN Chaoqun, WANG Mei, FENG Qiang, WANG Jingjing, WU Dongming, SUN Zonghao, ZHU Jiarong, WU Yini   +7 more
doaj   +1 more source

The Organizational Fitness Navigator: Creating and Measuring Organizational Fitness for Fast-Paced Transformation [PDF]

In the fast-changing environment of today dynamic capabilities to manage organizational transformation are regarded as crucial for business survival and improved performance.
Voelpel, Sven C., Leibold, Marius, Mahmoud, Khalid M.   +2 more
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Medical fitness for work in physicians with psychiatric disorders

European Psychiatry
Introduction Being a doctor is a profession with special medical requirements. Therefore, the assessment of medical fitness for work among physicians remains a complex decision, particularly for those with psychiatric disorders.
S. Chemingui, D. Brahim, I. Youssfi, M. Mersni, M. Methni, H. Ben Said, N. Mechergui, I. Yaich, C. Ben Said, N. Bram, N. Ladhari   +10 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source