Results 51 to 60 of about 684,983 (316)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Carbohydrate ingestion does not suppress increases in fatty acid-binding protein 4 concentrations post-acute aerobic exercise in healthy men: a randomized crossover study

BMC Sports Science, Medicine and Rehabilitation
Background Fatty acid-binding protein 4 (FABP4) has been associated with cardiovascular disease and diabetes. Acute aerobic exercise increases circulating FABP4 concentrations, but the underlying mechanisms remain unclear.
Shigeharu Numao, Ryota Uchida, Takashi Kurosaki, Masaki Nakagaichi   +3 more
doaj   +1 more source

Spatiotemporal and Kinetic Determinants of Sprint Acceleration Performance in Soccer Players

Sports, 2018
We aimed to elucidate spatiotemporal and kinetic determinants of sprint acceleration performance in soccer players. Thirty-seven male soccer players performed 60-m sprints.
Munenori Murata, Yohei Takai, Hiroaki Kanehisa, Tetsuo Fukunaga, Ryu Nagahara   +4 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Spatiotemporal and Ground Reaction Force Determinants of Sprint Acceleration in Adolescent Male Baseball Players [PDF]

The Asian Journal of Kinesiology
OBJECTIVES This study examined the relationships of changes in running speed with spatiotemporal (e.g., step length and frequency) and ground reaction force (GRF) variables during a 30-m sprint acceleration in adolescent baseball players to identify the ...
Tomoya Hirano, Chiharu Suzuki, Keisuke Oosawa, Hiroo Takahashi, Ryu Nagahara   +4 more
doaj   +1 more source

ABSOLUTE FITNESS, RELATIVE FITNESS, AND UTILITY [PDF]

Evolution, 2007
It is well known that (1) natural selection typically favors an allele with both a large mean fitness and a small variance in fitness; and (2) investors typically prefer a portfolio with both a large mean return and a small variance in returns. In the case of investors, this mean-variance trade-off reflects risk aversion; in the case of evolution, the ...
openaire   +2 more sources

Does living in urban or rural settings affect aspects of physical fitness in children? An allometric approach. [PDF]

, 2005
The aim of this study was to investigate physical fitness in relation to fatness in urban and rural Greek children by means of allometric scaling. METHODS: The sample consisted of 360 (189 urban and 171 rural; age 12.3+/-0.42 years) boys and 247 (125 ...
Tsimeas, P. D., Koutedakis, Yiannis, Tsiokanos, A.L., Tsimeas, P.D., Kellis, S., Tsimeas, Panagiotis D., Koutedakis, Y., Tsiokanos, Athanasios, Kellis, Spiros, Tsigilis, N., Tsiokanos, A. L.   +10 more
core   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

‘Virtual’ mentoring: can the principle of cognitive pairing increase its effectiveness? [PDF]

International Journal of Evidence Based Coaching and Mentoring, 2006
This paper is based on the experiences of completing a virtual mentoring programme within the higher education sector that used the principle of ‘cognitive pairing’ to enable the rapid establishment of high quality mentoring relationships.
Fiona Beddoes-Jones, Julia Miller
doaj  

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source