Results 71 to 80 of about 684,983 (316)

Alcohol and tobacco dependence among medical practitioners

European Psychiatry
Introduction Excessive use of tobacco, alcohol and other illicit drugs has a negative impact on the physical and mental health and work capacity of users. Physicians are no exception to these dreadful practices.
A. Belkahla, D. Brahim, I. Yaich, C. Ben Said, A. Ghenim, M. Mersni, H. Ben Said, N. Mechergui, I. Youssef, G. Bahri, N. Bram, N. Ladhari   +11 more
doaj   +1 more source

A Comparison of Children’s Fitness in the Northwest and Southwest of England

, 2014
The data from this paper was gathered from a larger cross-sectional study examining children’s physical activity participation in the Northwest and the Southwest of England. The purpose of this study was to carry out a battery of health and fitness tests
Boyle, Spencer
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Sports Medicine & Fitness News (1985 Spring)

, 1985
Sports Medicine Fitness Center. (1985). Sports Medicine & Fitness News (1985 Spring).
Sports Medicine Fitness Center
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Sports Medicine & Fitness News (1985 Fall)

, 1985
Sports Medicine Fitness Center. (1985). Sports Medicine & Fitness News (1985 Fall).
Sports Medicine Fitness Center
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Deafness and depression in the workplace: is there an association?

European Psychiatry
Introduction Chronic exposure to damaging noise can lead to hearing loss . People suffering from hearing problems find it increasingly difficult to communicate and become withdrawn. This lack of contact can lead to the onset of anxiodepressive disorders
W. Ayed, D. Brahim, I. Yaich, C. Bensaid, L. Houissa, N. Mechergui, H. Bensaid, M. Mersni, G. Bahri, I. Youssef, M. Bani, N. Bram, N. Ladhari   +12 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Quality of sleep among trainee doctors at the Charles Nicolle Hospital after vaccination against COVID19

European Psychiatry
Introduction Sleep quality depends on several factors such as smoking, physical activity, diet, and certain pathologies, namely obstructive sleep apnoea syndrome.
Z. Athimni, G. Bahri, M. Mersni, I. Youssef, D. Brahim, H. Ben Said, N. Mechergui, N. Ladhari, K. Imene   +8 more
doaj   +1 more source