Results 71 to 80 of about 799,230 (312)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Fitness

, 2018
Fitness data for figure S2.
Vaughn S. Cooper (251054), Marshall, Christopher W., Caroline B. Turner (828321), Turner, Caroline B., Cooper, Vaughn S., Christopher W. Marshall (645094)   +5 more
core   +2 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Measuring fitness of Kenyan children with polyparasitic infections using the 20-meter shuttle run test as a morbidity metric. [PDF]

, 2011
BACKGROUND: To date, there has been no standardized approach to the assessment of aerobic fitness among children who harbor parasites. In quantifying the disability associated with individual or multiple chronic infections, accurate measures of physical ...
Isabel M. Parraga, Bustinduy, Amaya L, Kitron Uriel, King, CH, Eric M. Muchiri, King, Charles H, Mungai Peter L., Fiutem, JJ, Justin J. Fiutem, Mutuku, Francis, Charles H King, Amaya L Bustinduy, Justin J Fiutem, Parraga Isabel M., Parraga, IM, Kitron, Uriel, Peter L Mungai, Peter L. Mungai, Uriel Kitron, Fiutem, Justin J, Thomas Charles L., Charles L. Thomas, King Charles H., Bustinduy Amaya L., Isabel M Parraga, Eric M Muchiri, Mutuku Francis, Mungai, Peter L, Bustinduy, AL, Muchiri, Eric M, Mutuku, F, Muchiri, EM, Fiutem Justin J., Thomas, Charles L, Charles H. King, Kitron, U, Parraga, Isabel M, Amaya L. Bustinduy, Mungai, PL, Francis Mutuku, Muchiri Eric M., Charles L Thomas, Thomas, CL   +42 more
core   +2 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Changes in Fitness, physical activity, fatness, and screen time: A longitudinal study in children and adolescents [PDF]

, 2009
*_Objective:_* To analyze whether changes in Physical Activity Index (PAI), sedentary time (ST; TV and PC use), and Body Mass Index (BMI) made a significant contribution to longitudinal changes in Physical Fitness (PF) of children and adolescents ...
Clarice Martins, Lars Bo Andersen, Denisa Mendonça, Maria Paula Santos, Jose Ribeiro, Gustavo Silva, Jorge Mota, Luisa Aires   +7 more
core  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Sports Medicine & Fitness News (1985 Fall)

, 1985
Sports Medicine Fitness Center. (1985). Sports Medicine & Fitness News (1985 Fall).
Sports Medicine Fitness Center
core