Results 91 to 100 of about 1,555,668 (297)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Exaptation and emergence as mechanisms to cross fitness valleys during evolution: an example using simulated homing behaviour [PDF]

, 2008
Evolution is often considered a gradual hill climbing process, slowly increasing the fitness of organisms. I investigate the evolution of homing behaviour in simulated intertidal limpets.
Richard Stafford
core   +1 more source

Adaptive walks on time-dependent fitness landscapes

, 1999
The idea of adaptive walks on fitness landscapes as a means of studying evolutionary processes on large time scales is extended to fitness landscapes that are slowly changing over time.
A. Babajide, A. Berry, B. Charlesworth, B. Levitan, B. Levitan, C. Adami, C. Reidys, C. V. Forst, C. V. Forst, C. W. Reynolds, D. Stauffer, E. van Nimwegen, H. I. Freedman, J. H. Gillespie, J. P. Crutchfield, J. S. Gale, J. W. Thatcher, K. Ishii, M. A. Huynen, M. Eigen, M. Kimura, M. Kreitman, M. Kreitman, M. Kreitman, R. Lande, S. A. Kauffman, S. A. Kauffman, S. A. Kauffman, S. Benner, T. Bäck, W. D. Hillis, W. J. Ewens   +31 more
core   +1 more source

Effects of aging on unloading-induced skeletal muscle atrophy and subsequent recovery in rats

Journal of Physical Fitness and Sports Medicine, 2013
Aged individuals with physiological muscle atrophy (sarcopenia) are likely forced into an unloading condition of inactivity such as bed rest and limb-immobilization.
Hideki Yamauchi, Yuki Takeda, Shino Tsuruoka, Shigeru Takemori   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Greedy adaptive walks on a correlated fitness landscape

, 2016
We study adaptation of a haploid asexual population on a fitness landscape defined over binary genotype sequences of length $L$. We consider greedy adaptive walks in which the population moves to the fittest among all single mutant neighbors of the ...
Krug, Joachim, Neidhart, Johannes, Park, Su-Chan   +2 more
core   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Effects of frequent, short-duration web-based light-intensity aerobic dance exercise on body composition, physical function, and physical activity in older adults: a randomized controlled trial

BMC Geriatrics
Background Physical inactivity remains a critical issue among older adults worldwide, contributing to functional decline and increased health risks. Traditional exercise programs face barriers such as accessibility and motivation. Web-based home exercise
Yuya Watanabe, Kazuki Hyodo, Daisuke Yamaguchi, Takayuki Noda, Sumiyo Nishida, Aiko Ueno, Yuko Kai, Takashi Arao   +7 more
doaj   +1 more source