Results 51 to 60 of about 91,473 (258)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
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Algorithms, 2021 Chimp Optimization Algorithm (ChOA), a novel meta-heuristic algorithm, has been proposed in recent years. It divides the population into four different levels for the purpose of hunting.
Di Wu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
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Correlation between Hemoglobin Concentration and Cardiorespiratory Fitness in Adolescent Sportsmen
Althea Medical Journal, 2020 Background: Sport is a physical activity that increases human body oxygen demand. Hemoglobin has a major role to fulfill the oxygen demand. The body capacity to fulfill the increasing oxygen demand could be seen as cardiorespiratory fitness.
Billy Leoprayogo +3 more
doaj +1 more source
Large linear classification when data cannot fit in memory [PDF]
Proceedings of the 16th ACM SIGKDD international conference on Knowledge discovery and data mining, 2010 Recent advances in linear classification have shown that for applications such as document classification, the training process can be extremely efficient. However, most of the existing training methods are designed by assuming that data can be stored in the computer memory. These methods cannot be easily applied to data larger than the memory capacity
Hsiang-Fu Yu +3 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Porsenasma Athlete Physical Fitness Classification
Halaman Olahraga Nusantara, 2023 This research was conducted at PGRI Palembang University. The purpose of this study was to determine the classification of physical freshness of sports athletes at PGRI Palembang University. The method in this study is a quantitative descriptive research method. The research sample was 20 students who became sports athletes at PGRI Palembang University,
Agung Mahendra +3 more
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Blind equalization and Automatic Modulation Classification based on pdf fitting [PDF]
2015 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), 2015 In this paper, a blind equalizer based on probability density function (pdf) fitting is proposed. It does not require any prior information about the transmission channel or the emitted constellation. We also investigate Automatic Modulation Classification (AMC) for Quadrature Amplitude Modulation (QAM) based on the pdf of the equalized signal.
Fki, Souhaila +2 more
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
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