Results 61 to 70 of about 91,473 (258)

VALFORTA: a randomised trial to validate the FORTA (Fit fOR The Aged) classification [PDF]

Age and Ageing, 2016
to further validate the FORTA (Fit fOR The Aged) concept, a bicentric randomised, controlled trial was run in two geriatric clinics.patients (≥65 years, ≥3 drugs or ≥60 years, ≥6 drugs) with three relevant diseases and hospitalisation for ≥5 days were randomised. In the intervention, but not the control group, a FORTA team instructed ward physicians on
Wehling, Martin, Burkhardt, Heinrich, Kuhn-Thiel, Alexandra, Pazan, Farhad, Throm, Christina, Weiss, Christel, Frohnhofen, Helmut   +6 more
openaire   +3 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

An AI-based algorithm for analyzing physical activity and health-related fitness in youth

Scientific Reports
In recent years, with the country’s emphasis on national fitness, the health status of primary and secondary school students has become the focus of social attention.
Mei Lv, Jing Wang, Yunqiang Yang, Jinghua Zhong, Jianlou Yang, Chen Dong   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Classification System for Cardiorespiratory Fitness Based on a Sample of the Brazilian Population [PDF]

International Journal of Cardiovascular Sciences, 2019
Abstract Background: Peak oxygen consumption (VO2peak) is an important prognostic marker and its classification helps the cardiologist in the therapeutic decision-making process. The most commonly used cardiorespiratory fitness (CRF) classification has not been validated for the Brazilian population. Objective: To elaborate a CRF classification using a
Almeida, Antonio Eduardo Monteiro de, Santander, Igor Rafael Miranda Ferreira, Campos, Maria Izabel Macedo, Arévalo, Jorge René Garcia, Nascimento, João Agnaldo do, Ritt, Luiz Eduardo Fonteles, Belli, Karlyse Claudino, Ribeiro, Jorge Pinto, Stein, Ricardo   +8 more
openaire   +4 more sources

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

The peculiarities of motor fitness’ classification model of 6-10 years old girls

Pedagogics, Psychology, Medical-Biological Problems of Physical Training and Sports, 2017
The purpose of the research is determination of motor fitness’ classification model of 6-10 years old girls. Material and methods: in the research 6 years old girls (n=36), 7 years old girls (n=48), 8 years old girls (n=57), 9 years old girls (n=38), 10 ...
O.V. Ivashchenko, S.S. Iermakov, O.M. Khudolii   +2 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

PENGARUH PERMAINAN OUTBOUND MYSTIQUE BALL TERHADAP TINGKAT KEBUGARAN JASMANI SISWA

Active: journal of physical education, sport, health and recreation, 2016
The purpose of this study was to determine the effect of outbound mystique ball game on the level of physical fitness class VIII SMP Negeri 1 Kesesi Pekalongan in 2016.
Vivi Septiana Parista, Endang Sri Hanani, Ipang Setiawan   +2 more
doaj