Results 91 to 100 of about 49,034 (303)
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Sendero: An Extended, Agent-Based Implementation of Kauffman's NKCS Model [PDF]
The idea of agents exploring a fitness landscape in which they seek to move from 'fitness valleys' to higher 'fitness peaks' has been presented by Kauffman in the NK and NKCS models.
Julian Padget +4 more
core
Interpretable Optimization: Why and How We Should Explain Optimization Models
Applied SciencesInterpretability is widely recognized as essential in machine learning, yet optimization models remain largely opaque, limiting their adoption in high-stakes decision-making.
Sara Lumbreras, Pedro Ciller
doaj +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick +19 more
wiley +1 more source
Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang +4 more
wiley +1 more source
A Fitness Landscape-Based Method for Extreme Point Analysis of Part Surface Morphology
MachinesAdvancements in Industry 4.0 and smart manufacturing have increased the demand for precise and intricate part surface geometries, making the analysis of surface morphology essential for ensuring assembly precision and product quality. This study presents
Jinshan Sun, Wenbin Tang
doaj +1 more source
Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs +7 more
wiley +1 more source
The Organizational Fitness Navigator: Creating and Measuring Organizational Fitness for Fast-Paced Transformation [PDF]
In the fast-changing environment of today dynamic capabilities to manage organizational transformation are regarded as crucial for business survival and improved performance.
Voelpel, Sven C. +2 more
core
To comprehend how pollination services can be maintained in increasingly anthropized landscapes is essential to understand how plant-pollinator interactions vary along disturbance gradients influencing community function.
Gómez-Martínez, Carmelo +3 more
core +1 more source