Results 71 to 80 of about 49,034 (303)

Adaptation to mutational inactivation of an essential gene converges to an accessible suboptimal fitness peak

eLife, 2019
The mechanisms of adaptation to inactivation of essential genes remain unknown. Here we inactivate E. coli dihydrofolate reductase (DHFR) by introducing D27G,N,F chromosomal mutations in a key catalytic residue with subsequent adaptation by an automated ...
João V Rodrigues, Eugene I Shakhnovich
doaj   +1 more source

Compensatory adaptation and diversification subsequent to evolutionary rescue in a model adaptive radiation

Ecology and Evolution, 2021
Biological populations may survive lethal environmental stress through evolutionary rescue. The rescued populations typically suffer a reduction in growth performance and harbor very low genetic diversity compared with their parental populations.
Dong‐Hao Zhou, Quan‐Guo Zhang
doaj   +1 more source

Novelty Search Promotes Antigenic Diversity in Microbial Pathogens

Pathogens, 2023
Driven by host–pathogen coevolution, cell surface antigens are often the fastest evolving parts of a microbial pathogen. The persistent evolutionary impetus for novel antigen variants suggests the utility of novelty-seeking algorithms in predicting ...
Brandon Ely, Winston Koh, Eamen Ho, Tasmina M. Hassan, Anh V. Pham, Weigang Qiu   +5 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

The Fitness Landscape of Translation [PDF]

, 2020
In this thesis I examine the fitness effects in the translation step of protein synthesis. The idea for this topic originates from the surprising findings of Zwart et al. in 2018 [35].
Josupeit, Mario
core  

The landscape of antibody binding affinity in SARS-CoV-2 Omicron BA.1 evolution

eLife, 2023
The Omicron BA.1 variant of SARS-CoV-2 escapes convalescent sera and monoclonal antibodies that are effective against earlier strains of the virus. This immune evasion is largely a consequence of mutations in the BA.1 receptor binding domain (RBD), the ...
Alief Moulana, Thomas Dupic, Angela M Phillips, Jeffrey Chang, Anne A Roffler, Allison J Greaney, Tyler N Starr, Jesse D Bloom, Michael M Desai   +8 more
doaj   +1 more source

Decision making on fitness landscapes [PDF]

Physica A: Statistical Mechanics and its Applications, 2017
We discuss fitness landscapes and how they can be modified to account for co-evolution. We are interested in using the landscape as a way to model rational decision making in a toy economic system. We develop a model very similar to the Tangled Nature Model of Christensen et. al. that we call the Tangled Decision Model.
Arthur, Rudy, Sibani, Paolo
openaire   +2 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A Picture Guide to Cancer Progression and Evolutionary Accumulation Models: Systematic Critique, Plausible Interpretations, and Alternative Uses

IEEE Access
Cancer progression and evolutionary accumulation models were developed to discover dependencies in the irreversible acquisition of binary traits from cross-sectional data.
Ramon Diaz-Uriarte, Iain G. Johnston
doaj   +1 more source

The peaks and geometry of fitness landscapes [PDF]

Journal of Theoretical Biology, 2013
Fitness landscapes are central in the theory of adaptation. Recent work compares global and local properties of fitness landscapes. It has been shown that multi-peaked fitness landscapes have a local property called reciprocal sign epistasis interactions. The converse is not true.
Crona, Kristina, Greene, Devin, Barlow, Miriam   +2 more
openaire   +2 more sources