Results 61 to 70 of about 49,034 (303)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Progressive gradient walk for neural network fitness landscape analysis
, 2018 Understanding the properties of neural network error landscapes is an important problem faced by the neural network research community. A few attempts have been made in the past to gather insight about neural network error landscapes using fitness ...
Mardé Helbig +5 more
core +1 more source
Inferring genetic interactions from comparative fitness data
eLife, 2017 Darwinian fitness is a central concept in evolutionary biology. In practice, however, it is hardly possible to measure fitness for all genotypes in a natural population.
Kristina Crona +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
A Problem Landscape Visualisation Method for Multi-Objective Optimisation
Mathematical and Computational ApplicationsUnderstanding the structure of multi-objective optimisation problems (MOPs) is essential for analysing search difficulty and supporting informed decision-making.
Zhiji Cui, Zimin Liang, Miqing Li
doaj +1 more source
Developmental feedbacks and the emergence of individuality
Royal Society Open Science, 2022 Behavioural individuality is a hallmark of animal life, with major consequences for fitness, ecology, and evolution. One of the most widely invoked explanations for this variation is that feedback loops between an animal's behaviour and its state (e.g ...
Sean M. Ehlman, Ulrike Scherer, Max Wolf
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Local Fitness Landscape Exploration Based Genetic Algorithms [PDF]
, 2023 Genetic algorithms (GAs) have been used to evolve optimal/sub-optimal solutions of many problems. When using GAs for evolving solutions, often fitness evaluation is the most computationally expensive, and this discourages researchers from applying GAs ...
Hickinbotham, Simon John +5 more
core +1 more source
Applications of High-Throughput Sequencing for In Vitro Selection and Characterization of Aptamers
Pharmaceuticals, 2016 Aptamers are identified through an iterative process of evolutionary selection starting from a random pool containing billions of sequences. Simultaneously to the amplification of high-affinity candidates, the diversity in the pool is exponentially ...
Nam Nguyen Quang +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source