Results 41 to 50 of about 49,034 (303)
Estimated phenotype-fitness landscape.
, 2022 (A–H) The phenotype-fitness landscape obtained using Gaussian smoothing for eight drugs is presented. The resistance levels were normalized to a maximum value of one (see Materials and methods).
Chikara Furusawa (76742) +5 more
core +1 more source
The fitness landscape of a tRNA gene [PDF]
Science, 2016 Epistasis and mutational fitness landscape A fitness landscape of a gene defines the molecular potential of evolution. This can help us understand the current state of evolution as well as predict unrealized potential. Using deep sequencing to examine mutations in nonessential genes that affect the growth of yeast
Chuan, Li +3 more
openaire +2 more sources
Fitness landscape for nucleosome positioning [PDF]
Proceedings of the National Academy of Sciences, 2013 Histone–DNA complexes, so-called nucleosomes, are the building blocks of DNA packaging in eukaryotic cells. The histone-binding affinity of a local DNA segment depends on its elastic properties and determines its accessibility within the nucleus, which plays an important role in the regulation of gene expression.
Donate, Weghorn, Michael, Lässig
openaire +2 more sources
Mutational robustness changes during long-term adaptation in laboratory budding yeast populations
eLife, 2022 As an adapting population traverses the fitness landscape, its local neighborhood (i.e., the collection of fitness effects of single-step mutations) can change shape because of interactions with mutations acquired during evolution.
Milo S Johnson, Michael M Desai
doaj +1 more source
Fitness landscape analysis of weight-elimination neural networks
, 2018 Neural network architectures can be regularised by adding a penalty term to the objective function, thus minimising network complexity in addition to the error.
Helbig, M, Bosman, A, Engelbrecht, AP
core +1 more source
Many Activities, One Structure: Functional Plasticity of Ribozyme Folds
Molecules, 2016 Catalytic RNAs, or ribozymes, are involved in a number of essential biological processes, such as replication of RNA genomes and mobile genetic elements, RNA splicing, translation, and RNA degradation.
Matthew W.L. Lau +1 more
doaj +1 more source
On simplified global nonlinear function for fitness landscape: a case study of inverse protein folding. [PDF]
PLoS ONE, 2014 The construction of fitness landscape has broad implication in understanding molecular evolution, cellular epigenetic state, and protein structures. We studied the problem of constructing fitness landscape of inverse protein folding or protein design ...
Yun Xu, Changyu Hu, Yang Dai, Jie Liang
doaj +1 more source
Inferring protein fitness landscapes from laboratory evolution experiments.
PLoS Computational Biology, 2023 Directed laboratory evolution applies iterative rounds of mutation and selection to explore the protein fitness landscape and provides rich information regarding the underlying relationships between protein sequence, structure, and function.
Sameer D'Costa +4 more
doaj +1 more source
Experimental illumination of a fitness landscape [PDF]
Proceedings of the National Academy of Sciences, 2011 The genes of all organisms have been shaped by selective pressures. The relationship between gene sequence and fitness has tremendous implications for understanding both evolutionary processes and functional constraints on the encoded proteins. Here, we have exploited deep sequencing technology to experimentally determine the fitness of all possible ...
Hietpas, Ryan T. +2 more
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook +6 more
wiley +1 more source