Results 41 to 50 of about 43,570 (212)
Applications of High-Throughput Sequencing for In Vitro Selection and Characterization of Aptamers
Pharmaceuticals, 2016 Aptamers are identified through an iterative process of evolutionary selection starting from a random pool containing billions of sequences. Simultaneously to the amplification of high-affinity candidates, the diversity in the pool is exponentially ...
Nam Nguyen Quang +2 more
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Developmental feedbacks and the emergence of individuality
Royal Society Open Science, 2022 Behavioural individuality is a hallmark of animal life, with major consequences for fitness, ecology, and evolution. One of the most widely invoked explanations for this variation is that feedback loops between an animal's behaviour and its state (e.g ...
Sean M. Ehlman, Ulrike Scherer, Max Wolf
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
eLife, 2019 The mechanisms of adaptation to inactivation of essential genes remain unknown. Here we inactivate E. coli dihydrofolate reductase (DHFR) by introducing D27G,N,F chromosomal mutations in a key catalytic residue with subsequent adaptation by an automated ...
João V Rodrigues, Eugene I Shakhnovich
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Ecology and Evolution, 2021 Biological populations may survive lethal environmental stress through evolutionary rescue. The rescued populations typically suffer a reduction in growth performance and harbor very low genetic diversity compared with their parental populations.
Dong‐Hao Zhou, Quan‐Guo Zhang
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Novelty Search Promotes Antigenic Diversity in Microbial Pathogens
Pathogens, 2023 Driven by host–pathogen coevolution, cell surface antigens are often the fastest evolving parts of a microbial pathogen. The persistent evolutionary impetus for novel antigen variants suggests the utility of novelty-seeking algorithms in predicting ...
Brandon Ely +5 more
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Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
IEEE AccessCancer progression and evolutionary accumulation models were developed to discover dependencies in the irreversible acquisition of binary traits from cross-sectional data.
Ramon Diaz-Uriarte, Iain G. Johnston
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The landscape of antibody binding affinity in SARS-CoV-2 Omicron BA.1 evolution
eLife, 2023 The Omicron BA.1 variant of SARS-CoV-2 escapes convalescent sera and monoclonal antibodies that are effective against earlier strains of the virus. This immune evasion is largely a consequence of mutations in the BA.1 receptor binding domain (RBD), the ...
Alief Moulana +8 more
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