Results 21 to 30 of about 49,034 (303)

On the incongruence of genotype-phenotype and fitness landscapes.

open access: yesPLoS Computational Biology, 2022
The mapping from genotype to phenotype to fitness typically involves multiple nonlinearities that can transform the effects of mutations. For example, mutations may contribute additively to a phenotype, but their effects on fitness may combine non ...
Malvika Srivastava, Joshua L Payne
doaj   +1 more source

Fitness of Nutrition Regulation in a Caterpillar Pest Mythimna separata (Walker): Insights from the Geometric Framework

open access: yesInsects, 2023
In nature, plants can contain variable nutrients depending upon the species, tissue, and developmental stage. Insect herbivores may regulate their nutrient intake behaviorally and physio- logically when encountering different foods.
Shaolei Sun   +4 more
doaj   +1 more source

An Attraction Map Framework of a Complex Multi-Echelon Vehicle Routing Problem with Random Walk Analysis

open access: yesApplied Sciences, 2021
The paper aims to investigate the basin of attraction map of a complex Vehicle Routing Problem with random walk analysis. The Vehicle Routing Problem (VRP) is a common discrete optimization problem in field of logistics.
Anita Agárdi   +2 more
doaj   +1 more source

Quantifying the Evolutionary Constraints and Potential of Hepatitis C Virus NS5A Protein

open access: yesmSystems, 2021
RNA viruses, such as hepatitis C virus (HCV), influenza virus, and SARS-CoV-2, are notorious for their ability to evolve rapidly under selection in novel environments.
Lei Dai   +9 more
doaj   +3 more sources

Fitness landscape elemzési technikák áttekintése [PDF]

open access: yes, 2020
In this article, we present fitness landscape analysis techniques. Fitness landscape analysis can be important in optimization algorithms. When researchers develop a new algorithm, it is tested on benchmark data.
Kovács, László   +2 more
core   +1 more source

Human Search in a Fitness Landscape: How to Assess the Difficulty of a Search Problem

open access: yesComplexity, 2020
Computational modeling is widely used to study how humans and organizations search and solve problems in fields such as economics, management, cultural evolution, and computer science.
Oana Vuculescu   +3 more
doaj   +1 more source

Inclusion of the fitness sharing technique in an evolutionary algorithm to analyze the fitness landscape of the genetic code adaptability

open access: yesBMC Bioinformatics, 2017
Background The canonical code, although prevailing in complex genomes, is not universal. It was shown the canonical genetic code superior robustness compared to random codes, but it is not clearly determined how it evolved towards its current form.
José Santos, Ángel Monteagudo
doaj   +1 more source

Lighting up protein design

open access: yeseLife, 2022
Using a neural network to predict how green fluorescent proteins respond to genetic mutations illuminates properties that could help design new proteins.
Grzegorz Kudla, Marcin Plech
doaj   +1 more source

Measuring ruggedness in fitness landscapes [PDF]

open access: yesProceedings of the National Academy of Sciences, 2015
How important are interactions among mutations for adaptation? Obviously, no gene functions in isolation, but it is possible that assuming that mutations have independent effects could still give a good prediction for how adaptation proceeds. In PNAS, Nahum et al.
Jeremy Van Cleve, Daniel B. Weissman
openaire   +2 more sources

Fitness Landscape Analysis of Automated Machine Learning Search Spaces [PDF]

open access: yes, 2020
The field of Automated Machine Learning (AutoML) has as its main goal to automate the process of creating complete Machine Learning (ML) pipelines to any dataset without requiring deep user expertise in ML.
Cristiano G. Pimenta   +7 more
core   +1 more source

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