Results 11 to 20 of about 49,034 (303)
Experimental rugged fitness landscape in protein sequence space. [PDF]
PLoS ONE, 2006 The fitness landscape in sequence space determines the process of biomolecular evolution. To plot the fitness landscape of protein function, we carried out in vitro molecular evolution beginning with a defective fd phage carrying a random polypeptide of ...
Yuuki Hayashi +5 more
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Simulation-based fitness landscape analysis and optimisation of complex problems
Technological and Economic Development of Economy, 2015 Widespread hard optimisation problems in economics and logistics are characterised by large dimensions, uncertainty and nonlinearity and require more powerful methods of stochastic optimisation that traditional ones. Simulation optimisation is a powerful
Galina Merkuryeva, Vitaly Bolshakov
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A rugged yet easily navigable fitness landscape [PDF]
, 2023 Author contributions: A.P. and A.W. conceived the study and designed the experiments. A.P., L.G.-P. and J.A.E. carried out the experiments. A.P. and A.W. analyzed data. A.P. wrote computer code to carry out bioinformatic work, simulations, and analysis.
Papkou, Andrei +3 more
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New Journal of Physics, 2022 The fitness landscape is a critical concept in biophysics, evolutionary biology, and genetics that depicts fitness in the genotype space and visualizes the relationship between genotype and fitness.
Kenji Okubo, Kunihiko Kaneko
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Evolutionary constraints in fitness landscapes [PDF]
Heredity, 2018 In the last years, several genotypic fitness landscapes-combinations of a small number of mutations-have been experimentally resolved. To learn about the general properties of "real" fitness landscapes, it is key to characterize these experimental landscapes via simple measures of their structure, related to evolutionary features.
Ferretti, Luca +3 more
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Cover-Encodings of Fitness Landscapes [PDF]
Bulletin of Mathematical Biology, 2018 15 pages, 4 ...
Klemm, Konstantin +2 more
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Frontiers in Molecular Biosciences, 2022 Ribozymes are RNA molecules that catalyze biochemical reactions. Self-cleaving ribozymes are a common naturally occurring class of ribozymes that catalyze site-specific cleavage of their own phosphodiester backbone. In addition to their natural functions,
James D. Beck +7 more
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Entropy, 2021 Two-component systems (TCS) are signaling machinery that consist of a histidine kinases (HK) and response regulator (RR). When an environmental change is detected, the HK phosphorylates its cognate response regulator (RR). While cognate interactions were
Claude Sinner +4 more
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SELVa: Simulator of evolution with landscape variation.
PLoS ONE, 2020 Organisms evolve to increase their fitness, a process that may be described as climbing the fitness landscape. However, the fitness landscape of an individual site, i.e., the vector of fitness values corresponding to different variants at this site, can ...
Elena Nabieva, Georgii A Bazykin
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Properties of objective functions and search algorithms in multi-objective optimization problems
Российский технологический журнал, 2022 Objectives. A frequently used method for obtaining Pareto-optimal solutions is to minimize a selected quality index under restrictions of the other quality indices, whose values are thus preset.
A. V. Smirnov
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