Results 201 to 210 of about 515,021 (268)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Conformity to popular, not average, opinions: Models, data, and evolution. [PDF]

Proc Natl Acad Sci U S A
Denton KK, Feldman MW, Johannemann JF.
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Surface modification of carbon-based adsorbents derived from coal gasification slag for the efficient adsorption of trimethoprim. [PDF]

PLoS One
Yang Z, Liu J, Li Q.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Self-Fit vs. Professional-Fit Over-the-Counter Hearing Aids: A Randomized Clinical Trial. [PDF]

J Am Acad Audiol
Zheng Y, Sepanski J, Li L.
europepmc   +1 more source

Maternal TPO-Ab status modulates associations between gestational thyroid hormones and neonatal TSH in 10,154 Chinese mother-newborn pairs. [PDF]

Ther Adv Endocrinol Metab
Wang H, Xi S, Chen X, Zhan Z, Yuan X, Zhang B.   +5 more
europepmc   +1 more source

Indicator Selection for Life Prediction of Polyimide Enameled Wire for Aviation Generators and Method for Establishing Life Curve-Based on Bayesian Nonlinear Regression. [PDF]

Polymers (Basel)
Wang Z, Liu Y, Li T, Zhu P, Niu G, Du H.
europepmc   +1 more source

Selected Brain Metabolites and Mitochondrial DNA Copy Number as Potential Markers of Ongoing Neurodegeneration in Patients with Wolfram Syndrome. [PDF]

Metabolites
Zmysłowska-Polakowska E, Płoszaj T, Skoczylas S, Grzybowska-Adamowicz J, Barańska D, Matera K, Palatyńska-Ulatowska A, Młynarski W, Zmysłowska A, Ciborowski M.   +9 more
europepmc   +1 more source

Impact of hearing aid use on cognitive function in elderly individuals with hearing loss: a prospective study. [PDF]

Braz J Otorhinolaryngol
Velho HC, Schichi MASC, da Silveira Sassi TS, de Oliveira JRM, Neto R, Lourençone LFM.   +5 more
europepmc   +1 more source