Results 151 to 160 of about 5,888,630 (298)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Relationship Between Personality Traits and Psychological Well-Being in Childhood Obesity: A Cross-Sectional Study Following the Five-Factor Model. [PDF]

Early Interv Psychiatry
Sepúlveda AR, Gil Gómez-Lobo A, Rojo M, Del Blanco-Barredo MDC, Veiga ÓL.   +4 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Personality as mechanism: An integrative model of five-factor model personality traits as a mechanism between earlier life factors and cognitive aging. [PDF]

Curr Opin Psychol
Sutin AR, Luchetti M, Stephan Y, Terracciano A.   +3 more
europepmc   +1 more source

Distinguishing between trait emotional intelligence and the five-factor model of personality: additive predictive validity of emotional intelligence for negative emotional states. [PDF]

Heliyon, 2022
Sambol S, Suleyman E, Scarfo J, Ball M.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Intimate Partner Violence Perpetration and the Five-Factor Model of Personality: A Systematic Review. [PDF]

Trauma Violence Abuse
Dorling E, Onifade H, Browne K.
europepmc   +1 more source

Corrigendum to: Cortical morphometry of the five-factor model of personality: findings from the Human Connectome Project full sample. [PDF]

Soc Cogn Affect Neurosci, 2021
Owens MM, Hyatt CS, Gray JC, Carter NT, MacKillop J, Miller JD, Sweet LH.   +6 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Predicting physical activity by the personality styles of the five-factor model. [PDF]

Health Psychol
Weiss A, Costa PT, Collins KA, Ross LM, Huffman KM, Wolever RQ, Smith PJ, Hauser ER, Jiang R, Jakicic JM, Kraus WE, Siegler IC.   +11 more
europepmc   +1 more source