Results 61 to 70 of about 43,927 (298)
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Comparizon of Conventional and Unconventional 5-phase PM Motor Structures for Naval Applications [PDF]
Multi-phase motors are widely used in marine propulsion. In this paper, a Multi-machine modeling of Surface Mounted PM motors is presented and applied to a 5-phase one.
CHARPENTIER, Jean-Frederic +3 more
core
Phosphoinositides and inositol phosphates as molecular glues
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
This article constitutes an introductory part of the special section on Intelligent Fault Monitoring and Fault-Tolerant Control in Power Electronics, Drives and Renewable Energy Systems. In the current issue of the journal, the first part of this section
Malinowski Mariusz +2 more
doaj +1 more source
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
An improved fault tolerant for a five-phase induction machine under open gate transistor faults
Of the different outstanding merits of multiphase machines is their ability to run steadily with some phases open. Commonly, optimal current control (OCC) to remaining healthy phases is usually engaged to ensure a certain optimization criterion.
Elhussien A. Mahmoud +2 more
doaj +1 more source
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
This paper aims to develop an innovative sensorless control approach for a five-phase induction motor (IM) drive. The operation principle of the sensorless scheme is based on the sliding mode theory, within which a sliding mode observer (SMO) estimates ...
Mahmoud A. Mossa +4 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source

