Results 41 to 50 of about 5,691,422 (217)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2015 The Five Star Movement’s (M5S) astonishing success in the 2013 general election, which saw the Movement secure as many as 109 deputies and 54 senators, has moved the M5S off the streets and into the parliamentary arena. Although Five Star representatives
L. Pinto, A. Pedrazzani
core +1 more source
Book review: Beppe Grillo’s Five Star Movement: organisation, communication and ideology [PDF]
, 2015 In Beppe Grillo’s Five Star Movement: Organisation, Communication and Ideology the contributors cast a critical view over the history and development of one of the most controversial parties of contemporary Europe, the Five Star Movement, which started ...
Zarali, Kally
core +5 more sources
Euroscepticism and populism in Italy among party elites and the public
QOE-IJES, 2022 The recent history of European politics has been characterised by the mounting phenomena of populism and Euroscepticism. Some recent analyses discuss the possible convergence between the two, exemplified, above all, by the increased success of ...
Nicolò Conti +2 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Till Policy Do Us Part: What unites (and divides) the Five Star Movement and Lega electorates
Italian Political Science, 2019 Coalition governments are sometimes made up of parties with sharply differing priorities and policy preferences. This is the case of Italy’s governing alliance between the Lega and the Five Star Movement, hailed by the media as populist.
Linda Basile, Rossella Borri
doaj
Il voto nei quartieri di Roma dal 2000 al 2018
QOE-IJES, 2018 Social and economic inequalities between the city centre and peripheral belts persist for many years in Rome districts, in parallel to the on-going suburban sprawl.
Federico Tomassi
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source