Results 51 to 60 of about 5,691,422 (217)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Challenger parties in Parliament: the case of the Italian Five Star Movement
Italian Political Science, 2019 In 2013, the Five Star Movement (M5S) won representation for the first time in the Italian parliament, the heart of the institutions they criticised and aimed to reform.
Enrico Borghetto
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Riding the Populist Web: Contextualizing the Five Star Movement (M5S) in Italy
Politics and Governance, 2015 This article focuses on three mechanisms to explain the rise of populist movements across Europe. They are politicization of resentment, exploitation of social cleavages, and polarization of resentment and feelings of non-representation. We conceptualize
Liza Lanzone, Dwayne Woods
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Two Variants of the Digital Party: The Platform Party and the Networked Party
Partecipazione e Conflitto, 2020 This article focuses on the impact of online participation platforms on the internal organization and democracy of a set of emerging political parties such as the Five Star Movement, Podemos, France Insoumise, the Pirate Parties and Barcelona en Comu ...
Marco Deseriis
doaj +3 more sources
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
International Journal of Communication, 2019 The article examines the impact of two online participation platforms on the internal party democracy (IPD) of the Five Star Movement (5SM) in Italy and Podemos in Spain.
Marco Deseriis, Davide Vittori
doaj
Beppe Grillo's Five Star Movement
, 2015 In 2009 Beppe Grillo, a well known Italian comedian, established the Five Star Movement with the aim of sending a handful of citizens to municipal councils to act as the watchdog of a professional political class often perceived as corrupt and self ...
Filippo Tronconi
core +1 more source