Results 61 to 70 of about 5,691,422 (217)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Deliberativa, diretta o partecipativa?

open access: yesQuaderni di Sociologia, 2014
Representative democracy is currently challenged in all Western political systems. In Italy this challenge in recent years has been launched in a distinctive way by the Movimento Cinque Stelle (M5s, Five Star Movement).
Antonio Floridia, Rinaldo Vignati
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Standing apart together? Common traits of (new) challenger parties in the Italian parliament

open access: yesItalian Political Science, 2018
Following the 2018 election and a long phase of negotiations, Lega and the Five Star Movement (FSM) appointed the first cabinet in Western Europe that does not include any mainstream party family.
Elisabetta De Giorgi, António Dias
doaj  

Identikit dei giovani elettori romani del Movimento 5 Stelle

open access: yesQuaderni di Sociologia, 2017
The article presents the results of a research on the young Romans made during the election campaign for the election of the mayor of June 2016. We will focus our analysis on the characteristics of young Romans in relation to their party-political ...
Giovanni Di Franco
doaj   +1 more source

Beppe Grillo’s Five Star Movement: Organisation, Communication and Ideology

open access: yes, 2016
Recensione al libro: Beppe Grillo’s five star movement: organisation, communication and ideology, edited by Filippo Tronconi, Farnham: Ashgate, 2015, xiii + 237 pp., £58.50, hard cover, ISBN ...
GAGLIARDI, ALESSIO
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Candidati, eletti e temi del M5S in Toscana: una nuova offerta politica regionale

open access: yesQOE-IJES, 2016
The 2015 Italian local elections strengthen significantly the presence of the Five Star Movement (M5S) in Tuscany with the entry of new faces into more than 150 council members, including the city of Livorno.
Luca Pighini
doaj   +1 more source

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