Results 121 to 130 of about 918,085 (317)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Does poly-β-hydroxybutyrate interfere with nitrogen fixation in bacteroids?
, 2001 While most rhizobia accumulate poly--hydroxybutyrate (PHB) during free-living reproductive growth, not all of them are able to store the polymer in symbiotic life. The role of PHB during nitrogen fixation in bacteroid state is still unclear.
POVOLO, SILVANA, CASELLA, SERGIO
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Design and application of a new type of oropharyngeal airway (一种新型口咽通气道的设计与应用)
中西医结合护理The oropharyngeal airway plays a significant role in relieving glossoptosis and maintaining upper airway patency. However, traditional fixation methods suffer from shortcomings such as inadequate fixation stability and inconvenient strap adjustment ...
NIE Zenghe (聂增贺) +6 more
doaj +1 more source
Symbiotic nitrogen fixation Chapter 10
, 1965 Chapters 1 and 16 describe the origin of the nitrogen cycle, the distribution of nitrogen in the biosphere, and the processes, including fixation,that maintain equilibrium between molecular and combined nitrogen.
Nutman, P. S.
core
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Klebsiella oxytoca is an important microorganism for nitrogen fixation and chemical production. Here, we report an annotated draft genome of K. oxytoca strain M5al that contains 5,256 protein-coding genes and 95 structural RNAs, which provides a genetic ...
Cao, Z. +6 more
core +1 more source
Novel aspects of nitrogen-fixation
, 1977 Only a fraction of the total agricultural need for nitrogen comes from natural or synthetic fertilizers. The remainder is satisfied largely through the biological fixation of atmospheric nitrogen. Whilst this is most efficiently effected by the Rhizobium-
Witty, J. F. +3 more
core +1 more source