Results 111 to 120 of about 918,085 (317)

Physiological and N2-fixation-related traits for tolerance to drought in soybean progenies

open access: yes, 2019
: The objective of this work was to evaluate six soybean (Glycine max) genotypes for physiological traits and biological nitrogen fixation in drought conditions, and their capacity for recovery after rewetting, based on yield components.
Antonio Eduardo Pípolo (7855232)   +6 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Mechanical considerations in fracture fixation

open access: yes, 2012
Bone’s capacity to repair following trauma is both unique and astounding. However, fractures sometimes fail to heal. Hence, the goal of fracture treatment is the restoration of bone’s structure, composition and function.
Krishnakanth, Pushpanjali
core  

Impact of hazardous components on CO2 biofixation from synthetic flue gas using Chlorella sp. JPR-1 in a raceway pond photobioreactor [PDF]

open access: yes, 2013
This work aimed to investigate the effects of hazardous compounds (NO and SO2) in flue gas on Chlorella JPR-1 growth in a raceway pond photobioreactor at ambient temperature (30 °C) without pH control.
Andri Cahyo Kumoro   +5 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

SHORT SEGMENT FIXATION OF THORACOLUMBAR FRACTURES WITH PEDICLE FIXATION AT THE LEVEL OF THE FRACTURE

open access: yes, 2018
Thoracolumbar fractures are very frequent injuries, for both anatomical and biomechanical reasons. The most appropriate surgical treatment is still debatable.
Luigi Caruso
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Nitrogen Isotopes in the Global Ocean [PDF]

open access: yes, 2013
Nitrogen is an essential nutrient for life. Its low abundance throughout much of the sunlit surface ocean limits the growth of primary producers that form the base of ocean ecosystems.
Somes, Christopher J.   +1 more
core  

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