Results 101 to 110 of about 1,006,047 (302)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Clinical application of a novel hysteroscopic LNG-IUS non-suture fixation at the uterine fundus
Frontiers in MedicineObjectiveThis study aimed to explore the feasibility and clinical effects of a novel hysteroscopic levonorgestrel-releasing intrauterine system (LNG-IUS) non-suture fixation at the uterine fundus.MethodsFrom October 2023 to July 2024, a prospective study
Yi Yu +4 more
doaj +1 more source
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
The Journal of Arthroplasty, 1986 One of the major problems of implant surgery is the failure of the bone-cement interface. Because of such failures, observed with increasing frequency with the passage of time, biologic fixation of total joint implants by means of bone ingrowth has become the focus of considerable interest among orthopedic surgeons.
openaire +2 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Guiding binocular saccades during reading: a TMS study of the PPC
Frontiers in Human Neuroscience, 2011 Reading is an activity based on complex sequences of binocular saccades and fixations. During saccades, the eyes do not move together perfectly: saccades could end with a misalignment, compromising fused vision. During fixations, small disconjugate drift
Marine eVERNET +3 more
doaj +1 more source
The Slickee Boys and Judies Fixation concert flier - d.c. Space, Washington, D.C., October 22, 1979
, 1979 Flier advertising a concert featuring the punk and new wave bands the Slickee Boys and Judies Fixation (listed here as Judy's Fixation). The concert occurred at d.c. Space in Washington, D.C.
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
EEG and Eye Tracking Signatures of Target Encoding during Structured Visual Search
Frontiers in Human Neuroscience, 2017 EEG and eye tracking variables are potential sources of information about the underlying processes of target detection and storage during visual search. Fixation duration, pupil size and event related potentials (ERPs) locked to the onset of fixation or ...
Anne-Marie Brouwer +4 more
doaj +1 more source