Results 91 to 100 of about 1,501,543 (304)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Use of bioactive and bioinert implants at treatment of factures

Бюллетень сибирской медицины, 2012
Compare characteristics of medical implants with oxide and calcium-phosphate coatings for surgical treatment of fractures of the humerus to implement them in clinical practice.The work is based on an analysis of clinical observations and surgical ...
V. P. Popov
doaj   +1 more source

Attention, Fixation, and Change Blindness [PDF]

, 2017
The topic of this paper is the complex interaction between attention, fixation, and one species of change blindness. The two main interpretations of the target phenomenon are the ‘blindness’ interpretation and the ‘inaccessibility’ interpretation.
Cheng, Tony
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Salicylic and succinic acids as inducers of phytoimmunity in winter wheat for the management of powdery mildew (Blumeria graminis (DC) Speer f. sp. tritici)

BMC Plant Biology
Background Growth regulators play an important role in activating the main signal transduction pathways in response to stress, and their activity is key in the general mechanism to understanding the formation of phytoimmunity under biotic stress.
Tetiana Nyzhnyk, Marcin Kiedrzyński, Edyta Kiedrzyńska, Sergii Kots   +3 more
doaj   +1 more source

Mesenchymal stem cells with magnetic particles for the subretinal injection in ophthalmology

Oftalʹmologiâ, 2014
The technology of the cultivation of mesenchymal stem cells with magnetic particles for the subretinal injection was developed in this work. The estimation of the effect of magnetic particles on the proliferation and functional activity of mesenchymal ...
Yu. A. Beliy, A. A. Temnov, A. V. Tereshchenko, S. A. Mirgorodskaya   +3 more
doaj   +1 more source

Posterior short segment pedicle screw fixation for the treatment of thoracolumbar fracture

The Pan African Medical Journal, 2020
The choice of the type of stabilization device in the osteosynthesis of dorso-lumbar spine fractures remains a subject of controversy. The present study aims to evaluate the efficiency of short segment in patients suffering post-traumatic thoracolumbar ...
Mourad Aoui, Nizar Sahnoun, Mohamed Abid, Mahdi Maatoug, Majdi Hsairi, Yosr Hentati, Hassib Keskes   +6 more
doaj   +1 more source

Methodological aspects of determination of biological N-fixation of different forage legumes [Methodische Aspekte der Bestimmung der biologischen N-Fixierung verschiedener Futterleguminosen] [PDF]

, 2002
Knowledge about the amount of fixed nitrogen of different legume crops is very important for calculation of farm N balances. According to literature the choice of determination method may have an impact on the estimated amount of N fixed by a legume ...
Loges, Ralf, Taube, Friedhelm
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source