Results 91 to 100 of about 1,006,047 (302)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Overcoming design fixation through education and creativity methods [PDF]
, 2013 This paper reports an experiment on the topic design fixation using 12 teams of masters students working on three design problems from (Jansson and Smith 1991).
Onarheim, B. +3 more
core +3 more sources
Bone & Joint OpenAims: In fixation of the fibula in ankle fractures, the AO Foundation advocates using a lag screw and one-third tubular neutralization plate for simple patterns. Where a lag screw cannot be placed, bridging fixation is required.
William G. Fishley +6 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Experimental and Finite Element Studies of Acetabular Cement Pressurisation and Socket Fixation in Total Hip Replacement [PDF]
, 1997 PhDWith time, the rate of symptomatic acetabular component loosening accelerates and overtakes that of the femoral component as the principal reason for the revision of total hip replacement.
New, Andrew Michael Raymond
core +3 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
BMC Plant BiologyBackground Growth regulators play an important role in activating the main signal transduction pathways in response to stress, and their activity is key in the general mechanism to understanding the formation of phytoimmunity under biotic stress.
Tetiana Nyzhnyk +3 more
doaj +1 more source
Indian Journal of Ophthalmology, 2014 Objective: To investigate the correlations between aqueous concentrations of vascular endothelial growth factor (VEGF), monocyte chemoattractant protein-1 (MCP-1), soluble intracellular adhesion molecule-1 (sICAM-1) and diabetic macular edema (DME ...
Dan Zhu +3 more
doaj +1 more source
A Case of Atlanto-Axial Rotatory Fixation Requiring Internal Fixation
Introduction: Most cases of atlanto-axial rotatory fixation (AARF) respond well to conservative treatment. Few reports have described initial management strategies.
Yujiro Takeshita +5 more
core +1 more source
Aerobic nitrogen fixation in Azotobacter vinelandii [PDF]
, 1977 I ELECTRON DONATION TO NITROGENASEPaper I shows that the hypothesis, that a high ratio of (NADH + NADPH) / (NAD + + NADP + ) is the source of reducing power for nitrogenase in intact A.vinelandii, is invalid.
Haaker, H.B.C.M.
core