Results 81 to 90 of about 918,085 (317)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Use of bioactive and bioinert implants at treatment of factures

Бюллетень сибирской медицины, 2012
Compare characteristics of medical implants with oxide and calcium-phosphate coatings for surgical treatment of fractures of the humerus to implement them in clinical practice.The work is based on an analysis of clinical observations and surgical ...
V. P. Popov
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Long-term effects of a one-time application of flue gas desulfurization gypsum on the soil pore structure in sodic paddy fields

Agricultural Water Management
Saline–sodic soil suffer from a high content of exchangeable sodium ions in the soil colloid and the poor air and water permeability of the soil pore structure.
Jianzhong Guo, Bangyan Liu, Kangping Zhang, Zhentao Sun, Enbo Mo, Shujuan Wang, Jia Liu, Yan Li, Lizhen Xu, Yonggan Zhao   +9 more
doaj   +1 more source

Mesenchymal stem cells with magnetic particles for the subretinal injection in ophthalmology

Oftalʹmologiâ, 2014
The technology of the cultivation of mesenchymal stem cells with magnetic particles for the subretinal injection was developed in this work. The estimation of the effect of magnetic particles on the proliferation and functional activity of mesenchymal ...
Yu. A. Beliy, A. A. Temnov, A. V. Tereshchenko, S. A. Mirgorodskaya   +3 more
doaj   +1 more source

Posterior short segment pedicle screw fixation for the treatment of thoracolumbar fracture

The Pan African Medical Journal, 2020
The choice of the type of stabilization device in the osteosynthesis of dorso-lumbar spine fractures remains a subject of controversy. The present study aims to evaluate the efficiency of short segment in patients suffering post-traumatic thoracolumbar ...
Mourad Aoui, Nizar Sahnoun, Mohamed Abid, Mahdi Maatoug, Majdi Hsairi, Yosr Hentati, Hassib Keskes   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A Case of Atlanto-Axial Rotatory Fixation Requiring Internal Fixation

Introduction: Most cases of atlanto-axial rotatory fixation (AARF) respond well to conservative treatment. Few reports have described initial management strategies.
Yujiro Takeshita, Hiroki Fujita, Tomonori Morita, Atsushi Teramoto, Ryunosuke Fukushi, Shunsuke Tachibana   +5 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Salicylic and succinic acids as inducers of phytoimmunity in winter wheat for the management of powdery mildew (Blumeria graminis (DC) Speer f. sp. tritici)

BMC Plant Biology
Background Growth regulators play an important role in activating the main signal transduction pathways in response to stress, and their activity is key in the general mechanism to understanding the formation of phytoimmunity under biotic stress.
Tetiana Nyzhnyk, Marcin Kiedrzyński, Edyta Kiedrzyńska, Sergii Kots   +3 more
doaj   +1 more source