Results 121 to 130 of about 324,450 (325)
Population genetics of multigene families that are dispersed into two or more chromosomes.
Proceedings of the National Academy of Sciences of the United States of America, 1983 The evolution of multigene families whose members are dispersed into two or more nonhomologous chromosomes is studied from the standpoint of population genetics.
T. Ohta, G. A. Dover
semanticscholar +1 more source
Exact results for fixation probability of bithermal evolutionary graphs
, 2012 One of the most fundamental concepts of evolutionary dynamics is the "fixation" probability, i.e. the probability that a mutant spreads through the whole population.
Houchmandzadeh, Bahram, Vallade, Marcel
core +3 more sources
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
Markov models for accumulating mutations [PDF]
arXiv, 2007 We introduce and analyze a waiting time model for the accumulation of genetic changes. The continuous time conjunctive Bayesian network is defined by a partially ordered set of mutations and by the rate of fixation of each mutation. The partial order encodes constraints on the order in which mutations can fixate in the population, shedding light on the
arxiv
1 Understanding Gene Duplication Through Biochemistry and Population Genetics
, 2011 Gene duplication has emerged as an important process supporting the functional diversification of genes. Since publication of the seminal book Evolution by Gene Duplication by Ohno (1970), the hypothesis regarding the importance of gene duplication in ...
D. Liberles, G. Kolesov, K. Dittmar
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Clonal interference and Muller's ratchet in spatial habitats
, 2014 Competition between independently arising beneficial mutations is enhanced in spatial populations due to the linear rather than exponential growth of clones.
Family F +18 more
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Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Diversity of indigenous sheep of an isolated population
BMC Veterinary Research, 2018 Background Because of the influence of genetics on animal production and the risk of losing genetic diversity of naturally adapted breeds, this study evaluated the genetic diversity of sheep of the Morada Nova breed belonging to an animal science ...
Caroline Marçal Gomes David +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Soft sweeps II--molecular population genetics of adaptation from recurrent mutation or migration.
Molecular biology and evolution, 2006 In the classical model of molecular adaptation, a favored allele derives from a single mutational origin. This ignores that beneficial alleles can enter a population recurrently, either by mutation or migration, during the selective phase.
P. Pennings, J. Hermisson
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