Results 131 to 140 of about 317,820 (317)

THE POPULATION GENETICS OF ADAPTATION: THE ADAPTATION OF DNA SEQUENCES

Evolution; international journal of organic evolution, 2002
I describe several patterns characterizing the genetics of adaptation at the DNA level. Following Gillespie (1983, 1984, 1991), I consider a population presently fixed for the ith best allele at a locus and study the sequential substitution of favorable ...
H. Orr
semanticscholar   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Markov models for accumulating mutations [PDF]

arXiv, 2007
We introduce and analyze a waiting time model for the accumulation of genetic changes. The continuous time conjunctive Bayesian network is defined by a partially ordered set of mutations and by the rate of fixation of each mutation. The partial order encodes constraints on the order in which mutations can fixate in the population, shedding light on the
arxiv  

Evolution in random fitness landscapes: the infinite sites model

, 2007
We consider the evolution of an asexually reproducing population in an uncorrelated random fitness landscape in the limit of infinite genome size, which implies that each mutation generates a new fitness value drawn from a probability distribution $g(w)$.
Arnold B C, Bovier A, Bürger R, David H, Davidsen J Grassberger P Paczuski M, Devroye L, Feller W, Fisher R A, Franz S, Franz S, Gardiner C W, Gavrilets S, Gillespie J H, Jain K, Jain K, Joachim Krug, Kauffman S, Kauffman S A, Kimura M, Lässig M, Ohta T, Orr H A, Sire C, Stein D L, Su-Chan Park, Tachida H, Weinrich D M, Wright S   +27 more
core   +3 more sources

Soft sweeps II--molecular population genetics of adaptation from recurrent mutation or migration.

Molecular biology and evolution, 2006
In the classical model of molecular adaptation, a favored allele derives from a single mutational origin. This ignores that beneficial alleles can enter a population recurrently, either by mutation or migration, during the selective phase.
P. Pennings, J. Hermisson
semanticscholar   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Diversity of indigenous sheep of an isolated population

BMC Veterinary Research, 2018
Background Because of the influence of genetics on animal production and the risk of losing genetic diversity of naturally adapted breeds, this study evaluated the genetic diversity of sheep of the Morada Nova breed belonging to an animal science ...
Caroline Marçal Gomes David, Celia Raquel Quirino, Wilder Hernando Ortiz Vega, Aylton Bartholazzi Junior, Aparecida de Fátima Madella-Oliveira, Ricardo Lopes Dias Costa   +5 more
doaj   +1 more source

The rate of molecular evolution considered from the standpoint of population genetics.

Proceedings of the National Academy of Sciences of the United States of America, 1969
The rate of amino acid substitutions in the evolution of homologous proteins is remarkably constant. Furthermore, estimated rates of amino acid substitutions based on comparisons of the alpha hemoglobin chains of various mammals with that of the carp are
M. Kimura
semanticscholar   +1 more source

The Speed of Adaptation in Large Asexual Populations

, 2004
In large asexual populations, beneficial mutations have to compete with each other for fixation. Here, I derive explicit analytic expressions for the rate of substitution and the mean beneficial effect of fixed mutations, under the assumptions that the ...
Claus O. Wilke, Robertson Effect
core   +3 more sources

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source