Interplay between pleiotropy and secondary selection determines rise and fall of mutators in stress response. [PDF]
Mutators are clones whose mutation rate is about two to three orders of magnitude higher than the rate of wild-type clones and their roles in adaptive evolution of asexual populations have been controversial.
Muyoung Heo, Eugene I Shakhnovich
doaj +10 more sources
Reduction of a metapopulation genetic model to an effective one island model [PDF]
We explore a model of metapopulation genetics which is based on a more ecologically motivated approach than is frequently used in population genetics. The size of the population is regulated by competition between individuals, rather than by artificially imposing a fixed population size.
Alan J. McKane+8 more
arxiv +3 more sources
The propagation of a cultural or biological trait by neutral genetic drift in a subdivided population [PDF]
We study fixation probabilities and times as a consequence of neutral genetic drift in subdivided populations, motivated by a model of the cultural evolutionary process of language change that is described by the same mathematics as the biological process.
Barton+48 more
arxiv +3 more sources
Spatial population genetics with fluid flow [PDF]
The growth and evolution of microbial populations is often subjected to advection by fluid flows in spatially extended environments, with immediate consequences for questions of spatial population genetics in marine ecology, planktonic diversity and ...
R. Benzi+4 more
semanticscholar +1 more source
Invasion and effective size of graph-structured populations. [PDF]
Population structure can strongly affect evolutionary dynamics. The most general way to describe population structures are graphs. An important observable on evolutionary graphs is the probability that a novel mutation spreads through the entire ...
Stefano Giaimo+2 more
doaj +1 more source
Fixation index ( F _st) statistics provide critical insights into evolutionary processes affecting the structure of genetic variation within and among populations.
Siavash Salek Ardestani+1 more
semanticscholar +1 more source
Significant advances have been made to understand the genetic basis of breast cancer. High, moderate and low penetrance variants have been identified with inter-ethnic variability in mutation frequency and spectrum. Genome wide association studies (GWAS)
M. Boujemaa+6 more
semanticscholar +1 more source
Explaining spatial heterogeneity in population dynamics and genetics from spatial variation in resources for a large herbivore. [PDF]
Fine-scale spatial variation in genetic relatedness and inbreeding occur across continuous distributions of several populations of vertebrates; however, the basis of observed variation is often left untested.
Adrienne L Contasti+3 more
doaj +1 more source
Limiting Genotype Frequencies of Y-Linked Genes with a Mutant Allele in a Two-Sex Population
A two-type two-sex branching process is considered to model the evolution of the number of carriers of an allele and its mutations of a Y-linked gene. The limiting growth rates of the different types of couples and males (depending on the allele, mutated
Miguel González+2 more
doaj +1 more source
Interplay between extreme drift and selection intensities favors the fixation of beneficial mutations in selfing maize populations [PDF]
Abstract Population and quantitative genetic models provide useful approximations to predict long-term selection responses sustaining phenotypic shifts, and underlying multilocus adaptive dynamics. Valid across a broad range of parameters, their use for understanding the adaptive dynamics of small selfing populations undergoing strong ...
Arnaud Desbiez-Piat+3 more
openaire +6 more sources