Phenotypic heterogeneity in modeling cancer evolution. [PDF]
PLoS ONE, 2017 The unwelcome evolution of malignancy during cancer progression emerges through a selection process in a complex heterogeneous population structure. In the present work, we investigate evolutionary dynamics in a phenotypically heterogeneous population of
Ali Mahdipour-Shirayeh +3 more
doaj +10 more sources
Interplay between pleiotropy and secondary selection determines rise and fall of mutators in stress response. [PDF]
PLoS Computational Biology, 2010 Mutators are clones whose mutation rate is about two to three orders of magnitude higher than the rate of wild-type clones and their roles in adaptive evolution of asexual populations have been controversial.
Muyoung Heo, Eugene I Shakhnovich
doaj +6 more sources
Reduction of a metapopulation genetic model to an effective one island model [PDF]
Europhys. Lett. 122, 18001 (2018), 2017 We explore a model of metapopulation genetics which is based on a more ecologically motivated approach than is frequently used in population genetics. The size of the population is regulated by competition between individuals, rather than by artificially imposing a fixed population size.
Alan J. McKane +8 more
arxiv +3 more sources
The propagation of a cultural or biological trait by neutral genetic drift in a subdivided population [PDF]
Theoretical Population Biology (2007) 71 454, 2006 We study fixation probabilities and times as a consequence of neutral genetic drift in subdivided populations, motivated by a model of the cultural evolutionary process of language change that is described by the same mathematics as the biological process.
Barton +48 more
arxiv +3 more sources
Fixation dynamics of beneficial alleles in prokaryotic polyploid chromosomes and plasmids [PDF]
, 2022 Theoretical population genetics has been mostly developed for sexually reproducing diploid and for monoploid (haploid) organisms, focusing on eukaryotes.
Dagan, T. +3 more
core +2 more sources
The molecular clock of neutral evolution can be accelerated or slowed by asymmetric spatial structure. [PDF]
PLoS Computational Biology, 2015 Over time, a population acquires neutral genetic substitutions as a consequence of random drift. A famous result in population genetics asserts that the rate, K, at which these substitutions accumulate in the population coincides with the mutation rate ...
Benjamin Allen +5 more
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Mating system and speciation I: Accumulation of genetic incompatibilities in allopatry.
PLoS Genetics, 2022 Self-fertilisation is widespread among hermaphroditic species across the tree of life. Selfing has many consequences on the genetic diversity and the evolutionary dynamics of populations, which may in turn affect macroevolutionary processes such as ...
Lucas Marie-Orleach +2 more
doaj +1 more source
Hydrodynamic flow and concentration gradients in the gut enhance neutral bacterial diversity [PDF]
Proc. Natl. Acad. Sci. U.S.A., 119(1): e2108671119 (2022), 2021 The gut microbiota features important genetic diversity, and the specific spatial features of the gut may shape evolution within this environment. We investigate the fixation probability of neutral bacterial mutants within a minimal model of the gut that includes hydrodynamic flow and resulting gradients of food and bacterial concentrations.
arxiv +1 more source
Growth, competition and cooperation in spatial population genetics [PDF]
, 2012 We study an individual based model describing competition in space between two different alleles. Although the model is similar in spirit to classic models of spatial population genetics such as the stepping stone model, here however space is continuous ...
Allstadt +40 more
core +3 more sources
Linking Diversity and Differentiation
Diversity, 2010 Generally speaking, the term differentiation refers to differences between collections for the distribution of specified traits of their members, while diversity deals with (effective) numbers of trait states (types).
Hans-Rolf Gregorius
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